头颈部癌患者应用卢戈氏染色内镜早期检测食管第二原发肿瘤：系统评价和荟萃分析。
Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta-analysis.
机构信息
Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
出版信息
Head Neck. 2019 Apr;41(4):1122-1130. doi: 10.1002/hed.25548. Epub 2018 Dec 28.
BACKGROUND
Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy.
METHODS
A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies.
RESULTS
Fifteen studies with a total of 3386 patients were included. The average yield of esophageal-SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal-SPTs were classified as high-grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%.
CONCLUSION
Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal-SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.
背景
早期检测头颈部鳞状细胞癌（HNSCC）患者的食管第二原发肿瘤（SPTs）可以提高患者的生存率。本研究旨在通过卢戈氏染色内镜检查确定食管 SPTs 的诊断率。
方法
对所有可用数据库进行系统综述，以查找所有卢戈氏染色内镜筛查研究。
结果
共纳入 15 项研究，总计 3386 例患者。HNSCC 患者的食管-SPT 平均检出率为 15%。下咽（28%）或口咽（14%）肿瘤指数患者的患病率最高。食管-SPTs 中 49%为高级别异型增生，51%为浸润性癌。
结论
我们的研究结果显示，15%接受卢戈氏染色内镜检查的 HNSCC 患者被诊断为食管 SPT。基于这些结果，有足够的证据可以进行卢戈氏染色内镜检查，尤其是在亚洲患者人群中。
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