Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.
Eur J Med Chem. 2019 Feb 15;164:121-170. doi: 10.1016/j.ejmech.2018.11.026. Epub 2018 Dec 21.
The quinoline core possesses a vast number of biological activities such as anticancer, antimalarial, antimicrobial, antifungal, antitubercular and antileishmanial. The conventional classical synthetic methods require the use of expensive and harsh conditions such as high temperature. Currently the scientific communities are searching new methodology to eliminate the use of chemicals, solvents and catalysts, which are hazardous to human health as well as to environment. This review provides a concise overview of new dimensions of green chemistry approaches in designing quinoline scaffold that would encourage the researchers towards green chemistry as well as future application of these greener, non-toxic, environment friendly methods in designing quinoline scaffold.
喹啉核具有许多生物活性，如抗癌、抗疟、抗菌、抗真菌、抗结核和抗利什曼原虫。传统的经典合成方法需要使用昂贵和苛刻的条件，如高温。目前，科学界正在寻找新的方法学来消除对化学物质、溶剂和催化剂的使用，这些物质对人类健康和环境都有危害。本文综述了绿色化学方法在设计喹啉支架方面的新进展，鼓励研究人员采用绿色化学方法，并将这些更环保、无毒、对环境友好的方法应用于设计喹啉支架。
