State Key Laboratory of Applied Organic Chemistry, National Demonstration Center for Experimental Chemistry Education, School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
Chem Asian J. 2020 Jan 17;15(2):231-241. doi: 10.1002/asia.201901380. Epub 2019 Dec 18.
As one of the most widely investigated compound skeleton, quinolines possess important medicinal and biological activities. As such, a great number of literatures, including reviews, have reported various methodologies to construct quinolines. Recently, organocatalyzed reactions have attracted the attention of organic chemists due to its being "green" because the reactions avoid the use of toxic metals. In this review, various distinctive contributions are surveyed with specific emphasis on organocatalyzed reactions for quinoline core constructions.
作为研究最广泛的杂环骨架之一，喹啉具有重要的药用和生物活性。因此，大量文献，包括综述，报道了构建喹啉的各种方法。最近，由于反应避免使用有毒金属，因此有机催化反应因其“绿色”而引起了有机化学家的关注。在这篇综述中，调查了各种独特的贡献，并特别强调了有机催化反应在喹啉核心构建中的应用。
