Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital and Peking University Institute of Mental Health, Beijing 100191, China; Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
J Affect Disord. 2019 Mar 1;246:285-289. doi: 10.1016/j.jad.2018.12.020. Epub 2018 Dec 17.
Little is known about the demographic and clinical features of the atypical subtype of major depressive disorder (MDD) patients in China. This study set out to investigate the prevalence of atypical depression in MDD patients in China, and identify its demographic and clinical features.
The study was conducted in 13 major psychiatric hospitals or in the psychiatric units of general hospitals in China, and recruited a sample of 1172 patients diagnosed with MDD. The patients' demographic and clinical features and prescriptions of psychotropic drugs were collected using a standardized questionnaire designed for the study.
The prevalence of atypical depression was 15.3%. In multiple logistic regression analyses, compared to the non-atypical depression patients, the atypical depression patients were more likely to have depressive episodes with suicide ideation and attempts (OR = 1.49, 95% CI = 1.06, 2.10, P = 0.023), depressive episodes with psychotic features (OR = 2.15, 95% CI = 1.43, 3.22, P < 0.001), seasonal depressive episodes (OR = 1.77, 95% CI = 1.12, 2.78, P = 0.014), an earlier age of onset (OR = 0.98, 95% CI = 0.96, 0.99, P = 0.001), and lifetime depressive episodes (OR = 1.07, 95% CI = 1.01, 1.13, P = 0.020).
The assessment of atypical features was not based on a validated rating scale.
Our results indicate that atypical depression is common in Chinese patients with MDD. MDD with atypical features may be more severe and debilitating than patients with non-atypical features.
在中国，关于非典型性重性抑郁障碍（MDD）患者的人口统计学和临床特征知之甚少。本研究旨在调查中国 MDD 患者中出现非典型性抑郁的比例，并确定其人口统计学和临床特征。
该研究在中国的 13 家主要精神病院或综合医院的精神科病房进行，共招募了 1172 名被诊断为 MDD 的患者。使用专为该研究设计的标准化问卷收集患者的人口统计学和临床特征以及精神药物处方信息。
非典型性抑郁的患病率为 15.3%。在多项逻辑回归分析中，与非非典型性抑郁患者相比，非典型性抑郁患者更有可能出现伴有自杀意念和自杀企图的抑郁发作（OR=1.49，95%CI=1.06，2.10，P=0.023）、伴有精神病性特征的抑郁发作（OR=2.15，95%CI=1.43，3.22，P<0.001）、季节性抑郁发作（OR=1.77，95%CI=1.12，2.78，P=0.014）、更早的发病年龄（OR=0.98，95%CI=0.96，0.99，P=0.001）和一生中的抑郁发作次数（OR=1.07，95%CI=1.01，1.13，P=0.020）。
非典型特征的评估并非基于经过验证的评分量表。
我们的结果表明，非典型性抑郁在我国 MDD 患者中较为常见。具有非典型特征的 MDD 可能比不具有非典型特征的 MDD 更为严重和虚弱。
