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Cardiovascular disease is obNOXious: New insights into NoxA1 in smooth muscle phenotype.

作者信息

Orr A Wayne, Woolard Matthew D

机构信息

Departments of Pathology and Translational Pathobiology, LSU Health - Shreveport, Shreveport, LA 71130, United States; Departments of Cell Biology and Anatomy, LSU Health - Shreveport, Shreveport, LA 71130, United States; Departments of Cellular and Molecular Physiology, LSU Health - Shreveport, Shreveport, LA 71130, United States.

Departments of Microbiology and Immunology, LSU Health - Shreveport, Shreveport, LA 71130, United States.

出版信息

Redox Biol. 2019 Apr;22:101081. doi: 10.1016/j.redox.2018.101081. Epub 2018 Dec 19.

DOI:10.1016/j.redox.2018.101081
PMID:30594486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6435942/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f30/6435942/31c474c735df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f30/6435942/31c474c735df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f30/6435942/31c474c735df/gr1.jpg

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本文引用的文献

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Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension.高血压中的血管 Nox（NADPH 氧化酶）区室化、蛋白过度氧化和内质网应激反应。
Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.
2
Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation.通过过表达腺相关病毒介导的前蛋白转化酶枯草溶菌素9（PCSK9）和部分颈动脉结扎加速C57Bl6小鼠动脉粥样硬化的发展。
Lab Invest. 2017 Aug;97(8):935-945. doi: 10.1038/labinvest.2017.47. Epub 2017 May 15.
3
活性氧（ROS）、内膜增厚与亚临床动脉粥样硬化疾病
Front Cardiovasc Med. 2019 Aug 2;6:89. doi: 10.3389/fcvm.2019.00089. eCollection 2019.
Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective.
平滑肌细胞中多能性因子OCT4的激活具有抗动脉粥样硬化作用。
Nat Med. 2016 Jun;22(6):657-65. doi: 10.1038/nm.4109. Epub 2016 May 16.
4
Vascular Smooth Muscle Cells in Atherosclerosis.动脉粥样硬化中的血管平滑肌细胞
Circ Res. 2016 Feb 19;118(4):692-702. doi: 10.1161/CIRCRESAHA.115.306361.
5
NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease.衰老相关心血管疾病中NOX4烟酰胺腺嘌呤二核苷酸磷酸氧化酶依赖性线粒体氧化应激
Antioxid Redox Signal. 2015 Dec 20;23(18):1389-409. doi: 10.1089/ars.2014.6221. Epub 2015 Jul 14.
6
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.KLF4 依赖的平滑肌细胞表型调节在动脉粥样硬化斑块发病机制中起关键作用。
Nat Med. 2015 Jun;21(6):628-37. doi: 10.1038/nm.3866. Epub 2015 May 18.
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Free Radic Res. 2015 Feb;49(2):186-98. doi: 10.3109/10715762.2014.992893.
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