Laboratory of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, Italy; Laboratoire des Biomolécules, UMR 7203, Département de chimie, École Normale Supérieure, PSL Research University, Sorbonne Universités, UPMC Université Paris 06, CNRS, 24 rue Lhomond, 75005, Paris, France.
Laboratoire des Biomolécules, UMR 7203, Département de chimie, École Normale Supérieure, PSL Research University, Sorbonne Universités, UPMC Université Paris 06, CNRS, 24 rue Lhomond, 75005, Paris, France.
Arch Biochem Biophys. 2019 Mar 15;663:44-53. doi: 10.1016/j.abb.2018.12.030. Epub 2018 Dec 27.
Investigation of the role of saccharides and glycoconjugates in mechanisms of immune-mediated physiological and pathological conditions is a hot topic. In fact, in many autoimmune diseases cross-reactivity between sugar moieties exposed on exogenous pathogens and self-molecules has long been hinted. Several peptides have been reported as mimetics of glycans specifically interacting with sugar-binding antibodies. The seek for these glycoreplica peptides is instrumental in characterizing antigen mimicry pathways and their involvement in triggering autoimmunity. Therefore, peptides mimicking glycan-protein interactions are valuable molecular tools to overcome the difficulties of oligosaccharide preparations. The clinical impact of peptide-based probes for autoimmune diseases diagnosis and follow-up is emerging only recently as just the tip of the iceberg of an overlooked potential. Here we provide a brief overview of the relevance of the structural and functional aspects of peptide probes and their mimicry effect in autoimmunity mechanisms for promising applications in diagnostics and therapeutics.
研究糖和糖缀合物在免疫介导的生理和病理条件中的作用是一个热门话题。事实上，在许多自身免疫性疾病中，暴露在外源病原体和自身分子上的糖部分之间的交叉反应早已被暗示。已经有报道称，一些肽是与糖结合抗体特异性相互作用的聚糖模拟物。寻找这些糖类似肽对于表征抗原模拟途径及其在引发自身免疫中的作用至关重要。因此，模拟糖-蛋白相互作用的肽是克服寡糖制备困难的有价值的分子工具。基于肽的探针在自身免疫性疾病诊断和随访中的临床应用最近才刚刚出现，这只是一个被忽视的潜在领域的冰山一角。在这里，我们简要概述了肽探针的结构和功能方面及其在自身免疫机制中的模拟作用在诊断和治疗方面的应用前景。
