Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Division of Hematology-Oncology, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA.
Division of Hematology-Oncology, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA.
Reprod Toxicol. 2019 Mar;84:59-64. doi: 10.1016/j.reprotox.2018.12.009. Epub 2018 Dec 27.
The purpose of this study was to follow up on the reporting of neurodevelopmental disorders in children exposed in utero to Hyperemesis Gravidarum (HG). This was an exploratory descriptive study whereby neurodevelopmental outcomes of 267 children delivered by 177 mothers with HG were compared to neurodevelopmental outcomes from 93 children delivered by 60 unaffected mothers. Similar to at age 8, the children (now 12) exposed in utero to HG had over 3-fold increase in odds of neurodevelopmental disorders including attention, anxiety, sensory, sleep difficulty, and social development delay/social anxiety. However, with the longer follow-up, there was also a significant increase in Autism Spectrum Disorder (ASD), reported in 22/267 (8%) of children exposed to HG in utero and no unexposed children. As early intervention for ASD can be critical to prognosis, larger studies are urgently needed to determine whether ASD is associated with exposure to HG.
本研究旨在跟进在子宫内暴露于妊娠剧吐（HG）的儿童的神经发育障碍报告。这是一项探索性描述性研究，比较了 177 名患有 HG 的母亲所生的 267 名儿童和 60 名未受影响的母亲所生的 93 名儿童的神经发育结局。与 8 岁时相似，在子宫内暴露于 HG 的儿童神经发育障碍的几率增加了两倍以上，包括注意力、焦虑、感觉、睡眠困难和社交发育迟缓/社交焦虑。然而，随着随访时间的延长，还显著增加了自闭症谱系障碍（ASD），在 267 名暴露于 HG 的儿童中有 22 名（8%）和未暴露的儿童中没有报告。由于 ASD 的早期干预对预后至关重要，因此迫切需要开展更大规模的研究，以确定 ASD 是否与暴露于 HG 有关。
