Department of Radiology and Biomedical Imaging, Yale University, 300 Cedar Street, New Haven, CT, 06519, USA; Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Geneva Neuroscience Center, Department of Neuroscience, University of Geneva, Case Postale 60, 1211, Geneva, Switzerland; NCCR Affective Sciences, University of Geneva, Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland; Faculty of Psychology and Educational Science, University of Geneva, FPSE - 40, Boulevard du Pont-d'Arve, 1211, Geneva, Switzerland.
Neuroimage. 2019 Apr 1;189:106-115. doi: 10.1016/j.neuroimage.2018.12.049. Epub 2018 Dec 27.
Positive emotions facilitate cognitive performance, and their absence is associated with burdening psychiatric disorders. However, the brain networks regulating positive emotions are not well understood, especially with regard to engaging oneself in positive-social situations. Here we report convergent evidence from a multimodal approach that includes functional magnetic resonance imaging (fMRI) brain activations, meta-analytic functional characterization, Bayesian model-driven analysis of effective brain connectivity, and personality questionnaires to identify the brain networks mediating the cognitive up-regulation of positive-social emotions. Our comprehensive approach revealed that engaging in positive-social emotion regulation with a self-referential first-person perspective is characterized by dynamic interactions between functionally specialized prefrontal cortex (PFC) areas, the temporoparietal junction (TPJ) and the amygdala. Increased top-down connectivity from the superior frontal gyrus (SFG) controls affective valuation in the ventromedial and dorsomedial PFC, self-referential processes in the TPJ, and modulate emotional responses in the amygdala via the ventromedial PFC. Understanding the brain networks engaged in the regulation of positive-social emotions that involve a first-person perspective is important as they are known to constitute an effective strategy in therapeutic settings.
积极情绪有助于认知表现，而缺乏积极情绪则与精神疾病的负担有关。然而，调节积极情绪的大脑网络还不是很清楚，特别是在涉及积极的社交情境时。在这里，我们报告了一项多模态方法的综合证据，该方法包括功能磁共振成像 (fMRI) 脑激活、元分析功能特征、基于贝叶斯模型的有效大脑连接分析以及人格问卷，以确定调节积极社交情绪的认知调节的大脑网络。我们的综合方法表明，以自我参照的第一人称视角进行积极的社交情绪调节，其特征是功能特化的前额叶皮层 (PFC) 区域、颞顶联合 (TPJ) 和杏仁核之间的动态相互作用。来自上额回 (SFG) 的自上而下的连接增加，控制腹内侧和背侧 PFC 的情感评估、TPJ 中的自我参照过程，并通过腹内侧 PFC 调节杏仁核的情绪反应。了解涉及第一人称视角的积极社交情绪调节所涉及的大脑网络非常重要，因为它们在治疗环境中被认为是一种有效的策略。
