Liu Y X, Cajander S
Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing.
Sci Sin B. 1988 Jul;31(7):807-17.
Considerable data have shown that plasminogen activator (PA) may play an important role in the mechanism of ovulation. A recent report argued that PA is not a primary proteolytic enzyme for follicular rupture because a dose of indomethacin that blocked ovulation did not inhibit ovarian PA content. To further clarify the specific role of PA in the ovulation, we have carefully examined the effect of indomethacin on the secretion of PA in granulosa and theca-interstitial (TI) cells following hCG or GnRH agonist administration in PMSG-primed hypophysectomized immature rats. We have also studies in vitro action of this compound on PA secretion in granulosa cells. The results indicate that indomethacin can only suppress hCG- and GnRH agonist-induced PA secretion, but not suppress the ovarian content of these enzymes.
大量数据表明，纤溶酶原激活物（PA）可能在排卵机制中起重要作用。最近的一份报告认为，PA不是卵泡破裂的主要蛋白水解酶，因为一剂阻断排卵的吲哚美辛并未抑制卵巢PA含量。为了进一步阐明PA在排卵中的具体作用，我们仔细研究了吲哚美辛对促性腺激素释放激素（PMSG）预处理的垂体切除未成熟大鼠注射人绒毛膜促性腺激素（hCG）或促性腺激素释放激素（GnRH）激动剂后颗粒细胞和卵泡膜间质（TI）细胞中PA分泌的影响。我们还研究了该化合物对颗粒细胞中PA分泌的体外作用。结果表明，吲哚美辛只能抑制hCG和GnRH激动剂诱导的PA分泌，但不能抑制这些酶在卵巢中的含量。
