Yang Lin, Yang Xingli, He Wenzhuo, Liu Shousheng, Jiang Chang, Xie Kunqian, Peng Kunwei, You Yafei, Zhang Bei, Xia Liangping
Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Aging (Albany NY). 2018 Dec 28;10(12):4107-4119. doi: 10.18632/aging.101700.
Population-based evaluations of the incidence of metastatic colorectal cancer at diagnosis among different age groups are lacking. Therefore, we investigated the effects of age at diagnosis on metastatic colorectal cancer and patients' prognoses. The Surveillance, Epidemiology, and End Results database was used to identify patients diagnosed with metastatic colorectal cancer. Multivariate Cox regression analyses were performed to identify factors associated with poor survival. The Kaplan-Meier analysis was used to estimate survival differences between the subgroups. We identified 30,333 adult patients diagnosed with metastatic colorectal cancer between 2010 and 2014. The younger and middle-aged groups had better survival than the older group when brain metastasis was not involved. The liver was the most common site of metastasis followed by the liver and lung combined. Age at diagnosis was an independent factor in patients' survival. Survival differences between two and three-sites of metastases were found in the middle-aged and older groups but not in the younger group. No survival differences between three and four sites of metastases were found in any of the age groups. Therefore, the incidence and prognosis of metastatic sites for metastatic colorectal cancer varied by age group.
目前缺乏针对不同年龄组在诊断时转移性结直肠癌发病率的基于人群的评估。因此，我们研究了诊断时的年龄对转移性结直肠癌及患者预后的影响。利用监测、流行病学和最终结果数据库来识别被诊断为转移性结直肠癌的患者。进行多变量Cox回归分析以确定与生存不良相关的因素。采用Kaplan-Meier分析来估计亚组之间的生存差异。我们识别出了2010年至2014年间30333例被诊断为转移性结直肠癌的成年患者。在不涉及脑转移的情况下，年轻和中年组的生存率高于老年组。肝脏是最常见的转移部位，其次是肝脏和肺联合转移。诊断时的年龄是影响患者生存的一个独立因素。在中年组和老年组中发现了两处和三处转移部位之间的生存差异，但在年轻组中未发现。在任何年龄组中，三处和四处转移部位之间均未发现生存差异。因此，转移性结直肠癌转移部位的发病率和预后因年龄组而异。
