和 位点与猪精液质量相关，这是通过群体关联研究发现的。
, and loci are associated with boar semen quality by population association studies.
机构信息
Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs & Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University , Wuhan , P. R. China.
College of Informatics, Huazhong Agricultural University , Wuhan , P. R. China.
出版信息
Anim Biotechnol. 2019 Oct;30(4):311-316. doi: 10.1080/10495398.2018.1521825. Epub 2018 Dec 31.
Spermatogenesis is a complex process regulated by many genes. In this study, , and genes were selected as candidate genes for boar semen quality traits based on their functions during spermatogenesis, and the associations of three loci ( c.192 + 210-192 + 213delCGAT, c.374 + 358 T > C and c.956 + 796 A > G) with sperm quality traits were analyzed in Duroc ( = 185), Large White ( = 87) and Landrace ( = 49) pig populations. The results showed c.192 + 210-192 + 213delCGAT AA boars produced 1.52% lower abnormal sperm rate (ASR) than AB boars in Landrace pigs ( < 0.05); c.374 + 358 TC boars produced 0.31 × 10/ml higher sperm concentration (SCON) than CC boars ( < 0.05) in Large White pigs; c.956 + 796 A > G was associated with ASR in Duroc and Large White pigs and was associated with sperm motility (MOT) in Large White and Landrace pigs. This study indicated the , and loci were the potential molecular markers for improving the semen quality traits in boars.
精子发生是一个受许多基因调控的复杂过程。本研究选择了 、 和 基因作为候选基因，基于它们在精子发生过程中的功能，分析了三个基因座（c.192+210-192+213delCGAT、c.374+358T>C 和 c.956+796A>G）与猪精液质量性状的相关性。在杜洛克猪（n=185）、长白猪（n=87）和大约克夏猪（n=49）群体中，结果表明，c.192+210-192+213delCGAT AA 基因型公猪的异常精子率（ASR）比 AB 基因型公猪低 1.52%（P<0.05）；c.374+358TC 基因型公猪的精子浓度（SCON）比 CC 基因型公猪高 0.31×10/ml（P<0.05）；c.956+796A>G 与杜洛克猪和长白猪的 ASR 相关，与长白猪和大约克夏猪的精子活力（MOT）相关。本研究表明，、和 基因座是提高公猪精液质量性状的潜在分子标记。
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