豆科植物[具体植物名称未给出]乙醇叶提取物对大鼠的止泻活性。
Antidiarrheal activity of Linn. (Fabaceae) ethanol leaf extract in rats.
作者信息
Pandhare Ramdas Bhanudas, Balakrishnan Sangameswaran, Bangar Gaurav Dnyandeo, Dighe Pramod Dnyandeo, Deshmukh Vinayak Kashinath
机构信息
Associate Professor and Head Department of Pharmacology, Maharashtra, India.
Principal and Professor, S.S.M. College of Pharmacy, Chinniampalayam, Jambai, Bhavani, Tamil Nadu, India.
出版信息
Ayu. 2018 Jan-Mar;39(1):40-45. doi: 10.4103/ayu.AYU_19_17.
BACKGROUND
Linn. (Fabaceae) is a plant which is traditionally used for the treatment of wide range of pharmacological activities including antimicrobial, antipyretic, anti-inflammatory, analgesic, diuretic, local anesthetic, antidiabetic, insecticidal, blood platelet aggregation-inhibiting and diarrhea in India. However, scientific evidence does not exist in any literature to corroborate the claim of therapeutic success of the plant species in diarrhea.
AIM OF THE STUDY
The core aim of the present study is to evaluate the antidiarrheal activity of ethanol extract (CTE).
MATERIALS AND METHODS
The antidiarrheal activity was evaluated using castor oil and magnesium sulfate (MgSO)-induced diarrhea method. The effects of CTE on gastrointestinal motility, intestinal transit and enteropooling were also examined in rats.
RESULTS
CTE (100-400 mg/kg, p.o.) produced dose-dependent and significant ( < 0.05-0.01) protection of rats against castor oil and MgSO-induced diarrhea, inhibited intestinal transit and delayed gastric emptying. CTE dose dependently and significantly delayed the onset of castor oil and MgSO-induced diarrhea, decreased the frequency of defecation and reduced the severity of diarrhea in the rats compared with loperamide (10 mg/kg, p.o.).
CONCLUSION
These findings confirm the ethno medicinal use of as a valuable natural remedy for the treatment, management and/or control of diarrhea.
背景
（豆科）是一种传统上用于治疗多种药理活性的植物，包括抗菌、解热、抗炎、镇痛、利尿、局部麻醉、抗糖尿病、杀虫、抑制血小板聚集以及在印度治疗腹泻。然而，在任何文献中都没有科学证据来证实该植物物种在腹泻治疗方面取得成功的说法。
研究目的
本研究的核心目的是评估乙醇提取物（CTE）的抗腹泻活性。
材料与方法
使用蓖麻油和硫酸镁（MgSO）诱导的腹泻方法评估抗腹泻活性。还在大鼠中研究了CTE对胃肠动力、肠道转运和肠内积液的影响。
结果
CTE（100 - 400毫克/千克，口服）对蓖麻油和MgSO诱导的腹泻产生剂量依赖性且显著（<0.05 - 0.01）的保护作用，抑制肠道转运并延迟胃排空。与洛哌丁胺（10毫克/千克，口服）相比，CTE剂量依赖性且显著地延迟了蓖麻油和MgSO诱导的腹泻发作，降低了大鼠的排便频率并减轻了腹泻的严重程度。
结论
这些发现证实了作为治疗、管理和/或控制腹泻的有价值天然药物的民族药用价值。
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