Barbu L A, Mărgăritescu N D, Şurlin M V
PhD student, Department Surgery, University of Medicine and Pharmacy of Craiova, Romania.
Department Surgery, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2017 Jul-Sep;43(3):191-200. doi: 10.12865/CHSJ.43.03.02. Epub 2017 Sep 28.
Esophageal varices are about 10%-15% of UGIB. Over 90% of patients with cirrhosis develop portal hypertension (PHT), but not all patients with PHT and liver cirrhosis have esophageal varices. At the time of diagnosis, only 60% of patients with cirrhosis have esophageal varices. In the case of variceal bleeding suspects, vasoactive drugs should be given as soon as possible and before endoscopy. Balloon tamponade is used to obtain temporary hemostasis by direct compression of hemorrhagic varices. The variceal band ligation is already the first place in the treatment and prevention of variceal bleeding, but also in rebleeding prevention. TIPS is used as a rescue therapy after failure of drug and endoscopic therapy. The mortality assigned to the hemorrhagic episode is substantially, estimated at 13-19% of the overall mortality in hepatic cirrhosis. Current recommendations for the treatment of acute variceal bleeding are the use of combination therapy: vasoactive drugs, balloon tamponade, elastic ligation and TIPS, whose staging is done in various diagnosis and treatment algorithms.
食管静脉曲张约占上消化道大出血(UGIB)的10% - 15%。超过90%的肝硬化患者会发生门静脉高压(PHT),但并非所有门静脉高压和肝硬化患者都有食管静脉曲张。在诊断时,只有60%的肝硬化患者有食管静脉曲张。对于疑似静脉曲张出血的情况,应在内镜检查前尽快给予血管活性药物。气囊压迫用于通过直接压迫出血的静脉曲张来实现临时止血。静脉曲张套扎术在治疗和预防静脉曲张出血方面已处于首位,在预防再出血方面也是如此。经颈静脉肝内门体分流术(TIPS)在药物和内镜治疗失败后用作挽救治疗。出血事件导致的死亡率很高,估计占肝硬化总体死亡率的13% - 19%。目前治疗急性静脉曲张出血的建议是采用联合治疗:血管活性药物、气囊压迫、弹力套扎和TIPS,其分期在各种诊断和治疗算法中进行。