Li Yang, Shi Dandan, He Xin, Wang Yongzhuang, Tang Yuhai, Zhang Junjie, Xu Silong
Department of Chemistry, School of Science, and Xi'an Key Laboratory of Sustainable Energy Materials Chemistry , Xi'an Jiaotong University , Xi'an 710049 , P. R. China.
J Org Chem. 2019 Feb 1;84(3):1588-1595. doi: 10.1021/acs.joc.8b02661. Epub 2019 Jan 10.
Alkynylcyclopropanes have been used for the first time as coupling partners in transition-metal-catalyzed C-H functionalization. Specifically, a Cp*Rh-catalyzed regioselective annulation of alkynylcyclopropanes with N-aryloxyamides via redox-neutral C-H/C-C activation has been developed, which affords highly functionalized 2,3-dihydrobenzofurans bearing an ( E)-exocyclic carbon-carbon double bond and a tetra-substituted carbon center in moderate to good yields with a broad substrate scope.
炔基环丙烷首次被用作过渡金属催化的C-H官能化反应中的偶联伙伴。具体而言，已经开发了一种通过氧化还原中性的C-H/C-C活化，利用Cp*Rh催化炔基环丙烷与N-芳氧基酰胺进行区域选择性环化反应，该反应能以中等至良好的产率提供带有（E）-环外碳-碳双键和四取代碳中心的高度官能化的2,3-二氢苯并呋喃，底物范围广泛。
