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Expression of human T-lymphocyte antigens by natural killer cells.

作者信息

Kaplan J, Callewaert D M

出版信息

J Natl Cancer Inst. 1978 May;60(5):961-4. doi: 10.1093/jnci/60.5.961.

DOI:10.1093/jnci/60.5.961
PMID:305967
Abstract

Rabbit antisera against human T-lymphocyte and B-lymphocyte antigens (anti-HTLA and anti-HBLA, respectively) were used to characterize natural killer (NK) cells mediating spontaneous cell-mediated cytotoxicity for myelogenous leukemia cell line K562 as measured in a 51Cr-release assay. NK activity of lymphocyte suspensions was abrogated by incubation of the suspensions in anti-HTLA plus complement but not by incubation in anti-HBLA plus complement. The effect of anti-HTLA was due to removal of NK cells rather than antigen-antibody complex inhibition of NK cells inasmuch as lytic complement was necessary. The results indicated that NK cells were HTLA+-HBLA- and thus supported the concept that NK cells are T-cells.

摘要

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引用本文的文献

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