环孢菌素A对小鼠自然杀伤活性的抑制作用。
Inhibition of mouse natural killer activity by cyclosporin A.
作者信息
Yanagihara R H, Adler W H
出版信息
Immunology. 1982 Feb;45(2):325-32.
Abstract
Cyclosporin A(CSA), administered in vivo or in vitro, inhibited the spontaneous cytotoxicity of C57BL/6 and NZB/WF1 mouse spleen cells against YAC and K562 target cells in a 4 hr 51Cr release assay. Inhibition of natural killing (NK) by CSA occurred rapidly, was dose-dependent, and did not require the presence of T cells, B cells or macrophages. CSA depressed NK activity by direct interaction with NK cells. There was no evidence that inhibition of NK by CSA was mediated through suppressor cells.
摘要
在体内或体外给予环孢菌素A（CSA），在4小时51铬释放试验中，可抑制C57BL/6和NZB/WF1小鼠脾细胞对YAC和K562靶细胞的自发细胞毒性。CSA对自然杀伤（NK）的抑制作用迅速出现，呈剂量依赖性，且不需要T细胞、B细胞或巨噬细胞的存在。CSA通过与NK细胞直接相互作用降低NK活性。没有证据表明CSA对NK的抑制是通过抑制细胞介导的。
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