Cho Jae Hoon, Suh Jeffrey D, Han Kyung-Do, Lee Heung Man
Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University College of Medicine, Seoul, Republic of Korea.
Department of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, California, U.S.A.
Laryngoscope. 2019 Apr;129(4):1005-1009. doi: 10.1002/lary.27294. Epub 2018 Dec 30.
To investigate the increase in the incidence of depression in patients with obstructive sleep apnea (OSA) and its preventability by uvulopalatopharyngoplasty (UPPP).
In this retrospective cohort study, data from the Korea National Health Insurance Corporation were analyzed. A total of 160,840 participants (age ≥ 20 years) who were newly diagnosed with OSA between 2007 and 2014 were included. The participants were classified into a group that underwent UPPP (UPPP group, n = 19,773) and a group that did not undergo surgical treatment (no surgery group, n = 141,067). Propensity score matching by age and sex was used to select the control group of 804,200 subjects. The mean follow-up duration was 4.6 ± 2.3 years. The primary endpoint was newly diagnosed depression.
The incidence of depression was higher in patients with OSA than in controls (hazard ratio [HR]: 1.678, 95% confidence interval [CI]: 1.650-1.706). The UPPP group was still at a higher risk of depression than was the control group (HR: 1.535, 95% CI: 1.463-1.610), but the HR was statistically lower than that in the no surgery group (HR: 1.694, 95% CI: 1.665-1.724).
OSA increases the incidence of depression, which may be prevented to some extent by UPPP.
2b Laryngoscope, 129:1005-1009, 2019.
探讨阻塞性睡眠呼吸暂停（OSA）患者抑郁发病率的增加情况及其通过悬雍垂腭咽成形术（UPPP）的可预防性。
在这项回顾性队列研究中，分析了韩国国民健康保险公团的数据。纳入了2007年至2014年间新诊断为OSA的160840名参与者（年龄≥20岁）。参与者被分为接受UPPP的组（UPPP组，n = 19773）和未接受手术治疗的组（非手术组，n = 141067）。采用年龄和性别倾向得分匹配法选择804200名受试者作为对照组。平均随访时间为4.6±2.3年。主要终点是新诊断的抑郁症。
OSA患者的抑郁发病率高于对照组（风险比[HR]：1.678，95%置信区间[CI]：1.650 - 1.706）。UPPP组的抑郁风险仍高于对照组（HR：1.535，95% CI：1.463 - 1.610），但该HR在统计学上低于非手术组（HR：1.694，95% CI：1.665 - 1.724）。
OSA增加了抑郁的发病率，UPPP可能在一定程度上预防这种情况。
2b《喉镜》，2019年，第129卷，第1005 - 1009页
