Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
Sci Rep. 2021 May 5;11(1):9608. doi: 10.1038/s41598-021-89205-4.
The purpose of this study was to investigate whether the incidence of Parkinson's disease (PD) is increased among patients with obstructive sleep apnea (OSA) and whether surgical treatment can prevent such an increase. This was a retrospective cohort study. We analysed the claims data from the Korea National Health Insurance Service. A total of 202,726 patients who were newly diagnosed with OSA between 2007 and 2014 were included. The patients were divided into two groups: patients who underwent uvulopalatopharyngoplasty (surgery group, n = 22,742) and those who did not (conservative group, n = 179,984). The control group (n = 1,013,630) was selected by propensity score matching. They were tracked until 31 December 2015. The hazard ratio of PD diagnosis (95% confidence interval) in the OSA group with respect to the control group was calculated using the Cox proportional hazard model. In the conservative group, the incidence of PD (hazard ratio 2.57 [2.32-2.85]) was significantly higher than that in the control group, while the incidence of PD in the surgery group was similar to that in the control group (hazard ratio 1.45 [0.89-2.22]). Patients with OSA are at an increased risk of developing PD, and uvulopalatopharyngoplasty may mitigate this risk.
本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）患者中帕金森病（PD）的发病率是否增加，以及手术治疗是否可以预防这种增加。这是一项回顾性队列研究。我们分析了来自韩国国家健康保险服务的数据。共纳入 2007 年至 2014 年间新诊断为 OSA 的 202726 例患者。患者分为两组：接受悬雍垂腭咽成形术（手术组，n=22742）和未接受手术（保守组，n=179984）的患者。选择对照组（n=1013630）进行倾向评分匹配。随访至 2015 年 12 月 31 日。使用 Cox 比例风险模型计算 OSA 组与对照组 PD 诊断的风险比（95%置信区间）。在保守组中，PD 的发病率（风险比 2.57 [2.32-2.85]）明显高于对照组，而手术组的 PD 发病率与对照组相似（风险比 1.45 [0.89-2.22]）。OSA 患者患 PD 的风险增加，悬雍垂腭咽成形术可能降低这种风险。
