Cheung L Y
Department of Surgery, University of Kansas Medical Center, Kansas City 66103.
Am J Surg. 1988 Dec;156(6):437-40. doi: 10.1016/s0002-9610(88)80522-1.
In the last decade, significant progress has been made in understanding the basic mechanisms involved in the development of acute stress gastritis. Many of the experimental observations have been applied in our clinical approaches to patients at high risk. A strong impression exists among investigators that efforts to improve ventilatory support, correct abnormalities in cardiac output and intravascular volume, and maintain adequate nutrition in critically ill patients may have contributed to the decreased incidence and prevalence of stress gastritis over the past decade. In addition, reduction of intragastric acidity, either by titration with antacids or administration of H2 antagonists, further prevented stress gastritis in these patients. We have every reason to believe that progress will continue at the same rate in the decades before us in this area of investigation.
在过去十年中，我们对急性应激性胃炎发病的基本机制的认识取得了重大进展。许多实验观察结果已应用于我们对高危患者的临床治疗中。研究人员强烈认为，在过去十年里，努力改善通气支持、纠正心输出量和血管内容量异常以及维持重症患者的充足营养，可能有助于降低应激性胃炎的发病率和患病率。此外，通过用抗酸剂滴定或给予H2拮抗剂来降低胃内酸度，进一步预防了这些患者的应激性胃炎。我们完全有理由相信，在我们未来几十年的研究中，这一领域将继续以同样的速度取得进展。
