Mete Uttam K, Shenvi Sunil, Singh Mini P, Chakraborti Anuradha, Kakkar Nandita, Ratho Radha Kanta, Mandal Arup K
Department of Urology, PGIMER, Chandigarh, India.
Consultant, Multiorgan Transplantation & HPB Surgery, Ruby Hall Clinic, Pune, India.
Int J Appl Basic Med Res. 2018 Oct-Dec;8(4):217-219. doi: 10.4103/ijabmr.IJABMR_91_18.
To study the role of high-risk human papillomavirus (HPV-16 and HPV-18) types in the causation of urothelial carcinoma of the urinary bladder in Indian population.
50 patients with Urothelial carcinoma of the urinary bladder were included in the study. Another 10 age-matched subjects who were hospitalized for transurethral resection of prostate for benign prostatic hyperplasia and/or ureterorenoscopy for ureteric stone disease were enrolled as controls. The tissue samples were analyzed for the presence of HPV-16 and HPV-18 DNA by polymerase chain reaction (PCR). The histopathology of the tumor tissue was carried out to assess the grade of the tumor.
The mean age of the patients was 54.1 years. A total of 28 (56%) patients had high-grade tumors and 22 (44%) had low-grade disease. T2 or higher stage disease was observed in 18 (36%) patients. All cancerous specimens and control specimens were found to be negative by PCR for the presence of HPV DNA.
HPV prevalence in the urothelium is very low irrespective of the stage and grade of the disease, and hence, it is unlikely to be the causative agent for urothelial carcinoma of the urinary bladder in Indian population. However, the role of other HPV types in the etiology of this tumor needs to be clarified.
研究高危型人乳头瘤病毒（HPV-16和HPV-18）在印度人群膀胱尿路上皮癌病因中的作用。
本研究纳入50例膀胱尿路上皮癌患者。另外选取10例年龄匹配的受试者作为对照，这些受试者因良性前列腺增生接受经尿道前列腺切除术住院治疗和/或因输尿管结石病接受输尿管肾镜检查。通过聚合酶链反应（PCR）分析组织样本中HPV-16和HPV-18 DNA的存在情况。对肿瘤组织进行组织病理学检查以评估肿瘤分级。
患者的平均年龄为54.1岁。共有28例（56%）患者患有高级别肿瘤，22例（44%）患有低级别疾病。18例（36%）患者观察到T2期或更高分期疾病。通过PCR检测发现所有癌组织标本和对照标本中HPV DNA均为阴性。
无论疾病的分期和分级如何，尿路上皮中HPV的流行率都非常低，因此，HPV不太可能是印度人群膀胱尿路上皮癌的致病因素。然而，其他HPV类型在该肿瘤病因中的作用需要进一步阐明。
