作为 psammaplin A 类似物的双三唑文库的平行合成：新一代抗生物膜化合物？
Parallel synthesis of a bis-triazoles library as psammaplin A analogues: A new wave of antibiofilm compounds?
机构信息
Université de Toulon, MAPIEM, Toulon, France.
Université de Toulon, MAPIEM, Toulon, France.
出版信息
Bioorg Med Chem Lett. 2019 Feb 15;29(4):614-618. doi: 10.1016/j.bmcl.2018.12.047. Epub 2018 Dec 21.
PMID:30600205
Abstract
Synthesis of psammaplin A analogues is described. Screening for antibiofilm activity of the targeted library afford some interesting elements in terms of structure-activity relationships. Some compounds exhibited EC50 in the range of ampicillin against three strains of gramnegative bacteria without toxic effect.
摘要
描述了 psammaplin A 类似物的合成。针对目标文库的抗生物膜活性筛选提供了一些有趣的结构-活性关系方面的内容。一些化合物对三种革兰氏阴性菌的 EC50 值在氨苄青霉素范围内，且没有毒性作用。
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