结直肠癌评估的生物标志物实用指南。
A practical guide to biomarkers for the evaluation of colorectal cancer.
机构信息
Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
出版信息
Mod Pathol. 2019 Jan;32(Suppl 1):1-15. doi: 10.1038/s41379-018-0136-1. Epub 2019 Jan 2.
Evaluation of microsatellite instability (MSI) of every colorectal cancer (CRC) is important for prognostic and therapeutic purposes, while molecular testing helps identify actionable targeted therapy for patients with metastatic disease. This review will discuss the biomarkers commonly encountered in the clinical evaluation of CRC, and practical issues regarding MSI screening, reporting, interpretation, molecular test indication, and specimen requirements.
评估每例结直肠癌（CRC）的微卫星不稳定性（MSI）对于预测和治疗目的很重要，而分子检测有助于确定转移性疾病患者的可行靶向治疗。本文将讨论在 CRC 的临床评估中常见的生物标志物，以及关于 MSI 筛选、报告、解释、分子检测适应证和标本要求的实际问题。
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