Naundorf H
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Arch Geschwulstforsch. 1988;58(5):345-56.
Syngeneically and xenogeneically transplanted hormone-dependent mammary carcinomas were used for therapeutic in vivo estimation of the effect of hormones and antihormones. During the transplantation the majority of the tumors of the rat shows development from hormone dependence to hormone independence and, consequently, chemically induced (DMBA, NMU) mammary carcinomas have been the subject of considerable interest. Hormone-dependent mammary carcinomas of the mouse (MXT, estradiol- and progesterone-induced tumors and pregnancy-dependent mammary tumors of different mouse strains) are suitable for estimation of the effects of hormones. Xenogeneically transplanted hormone-dependent human tumors (B0 or T61, Br-10, SE, MCF-7, ZR75-1) are introduced in testing of hormones. During the transplantation of human mammary carcinomas in nude mice the hormone receptor status is preserved, and it is possible to perform endocrine treatments in models of human mammary carcinomas.
同基因和异种移植的激素依赖性乳腺癌被用于激素和抗激素作用的体内治疗评估。在移植过程中，大多数大鼠肿瘤显示出从激素依赖性发展为激素非依赖性，因此，化学诱导（DMBA、NMU）的乳腺癌一直是相当受关注的对象。小鼠的激素依赖性乳腺癌（MXT、雌二醇和孕酮诱导的肿瘤以及不同小鼠品系的妊娠依赖性乳腺肿瘤）适用于评估激素的作用。异种移植的激素依赖性人类肿瘤（B0或T61、Br - 10、SE、MCF - 7、ZR75 - 1）用于激素测试。在裸鼠体内移植人类乳腺癌的过程中，激素受体状态得以保留，并且有可能在人类乳腺癌模型中进行内分泌治疗。
