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[自然高原低氧条件下胎盘的形态功能适应]

[Morphofunctional adaptation of the placenta under conditions of natural high-altitude hypoxia].

作者信息

Milovanov A P, Reshetnikova O S, Borzykh A N

出版信息

Arkh Patol. 1988;50(9):11-7.

PMID:3060048
Abstract

Twenty-six III trimester placentae from Kirghiz puerperas residents of high-altitude regions (2200-3000 m above the sea level) and 22 such placentae from female residents of the plains (group I and II, respectively) were subjected to ultrasonic placentometry and organo-stereohistometry. Group I placentae appeared to fall behind in thickness on weeks 28, 32 and 36 as well as in development on the last 4 weeks which is coupled with synchronous reduction of weight of mature newborns and relevant placentae. Enhanced morphofunctional activity, excessive vasculature of villous network, increased epithelial volume of the villi and vascular-syncytial membranes, intensive growth of separate cotyledons were characteristic for placentae exposed to high-altitude factors, which also bore the signs of dysadaptation manifesting with more frequent infarctions, adherent villi, hemorrhages.

摘要

对26例来自海拔2200 - 3000米高海拔地区吉尔吉斯产妇的晚期妊娠胎盘以及22例来自平原地区女性居民的此类胎盘(分别为第一组和第二组)进行了超声胎盘测量和器官立体组织测量。第一组胎盘在孕28周、32周和36周时厚度落后,且在最后4周发育落后,这与成熟新生儿及相关胎盘重量的同步减轻有关。暴露于高海拔因素的胎盘具有形态功能活性增强、绒毛网络血管过多、绒毛上皮体积增加以及血管合体膜增加、单个小叶生长旺盛的特征,同时也有适应不良的迹象,表现为梗死更频繁、绒毛粘连、出血。

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