Sert Yasemin, Ozgu-Erdinc A Seval, Saygan Sibel, Engin Ustun Yaprak
a University of Health Sciences Zekai Tahir Burak Women's Health Care, Training and Research Hospital , Ankara , Turkey.
Fetal Pediatr Pathol. 2019 Apr;38(2):112-120. doi: 10.1080/15513815.2018.1552732. Epub 2019 Jan 2.
The present study aimed to determine cytomegalovirus (CMV) seroprevalence, low and high avidities, and the frequency of polymerase chain reaction (PCR) positivity and neonatal disease in an obstetric population.
Sera of 32,188 women were tested for CMV IgM and/or CMV IgG between 2008 and 2017. Those with IgM were tested for antibody avidity. Of those with low avidity, PCR was offered.
The frequency of CMV IgG and IgM seropositivity was 62% (16,759/26,854) and 22% (74/32,188). The number with low avidity was 42. In 36/42, the infants were PCR tested for CMV and 9 were CMV positive. Only one infant had signs of congenital CMV infection at the time of birth.
This study shows the prevalence of Cytomegalovirus infections in a tertiary referral center in Turkey. Although universal screening is not recommended, it can be helpful for the prevention of congenital infection for seronegative women to be advised to at-risk patients due to high prevalence of CMV exposure.
本研究旨在确定产科人群中巨细胞病毒（CMV）的血清流行率、低亲和力和高亲和力情况，以及聚合酶链反应（PCR）阳性率和新生儿疾病的发生率。
对2008年至2017年间32188名女性的血清进行CMV IgM和/或CMV IgG检测。对IgM阳性者检测抗体亲和力。对低亲和力者进行PCR检测。
CMV IgG和IgM血清阳性率分别为62%（16759/26854）和22%（74/32188）。低亲和力者有42人。其中36/42例婴儿接受了CMV的PCR检测，9例呈CMV阳性。出生时只有一名婴儿有先天性CMV感染迹象。
本研究显示了土耳其一家三级转诊中心巨细胞病毒感染的流行情况。尽管不建议进行普遍筛查，但由于CMV暴露的高流行率，建议血清阴性的女性向高危患者咨询，这可能有助于预防先天性感染。
