a Department of Physics, Centre of Advanced Study in Physics , Punjab University , Chandigarh , India.
b Sri Guru Gobind Singh College , Chandigarh , India.
J Drug Target. 2019 Sep;27(8):813-829. doi: 10.1080/1061186X.2018.1561888. Epub 2019 Jan 11.
Nanoparticles have several exciting applications nowadays almost in every area. Biomedical field is one of them where nanoparticles show potential for various applications due to their exceptional and exciting properties. The presence of heavy metals in inorganic nanoparticles lead to toxicity in the biological system, therefore, their direct use for drug delivery is restricted. But encapsulating their surface with a non-toxic or biocompatible material makes them a promising material for application in drug delivery system. This review highlights the various characteristics and factors involved in nano-drug delivery system. The understanding of various mechanisms involved during the uptake of nanoparticles by cells, toxicity, surface chemistry and several drug release mechanisms has been discussed. This article also includes various computational studies used to optimise the design and properties of drug delivery system.
纳米粒子在现今的几乎各个领域都有令人兴奋的应用。生物医学领域就是其中之一，由于其特殊而令人兴奋的性质，纳米粒子在各种应用中显示出潜力。无机纳米粒子中重金属的存在导致生物系统中毒，因此，它们的直接应用受到限制。但是，用无毒或生物相容的材料包裹其表面，使它们成为药物传递系统应用的有前途的材料。本综述强调了纳米药物传递系统中涉及的各种特性和因素。讨论了细胞摄取纳米粒子过程中涉及的各种机制、毒性、表面化学和几种药物释放机制。本文还包括用于优化药物传递系统设计和性能的各种计算研究。
