Department of Pathology and Laboratory Medicine, University of California at Irvine, Orange.
Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA.
Adv Anat Pathol. 2019 Mar;26(2):75-83. doi: 10.1097/PAP.0000000000000222.
Goblet cell carcinoid (GCC) or goblet cell carcinoma is a unique mixed endocrine-exocrine neoplasm that is almost exclusively seen in the appendix. The hallmark of GCC is the concentric infiltration of the appendiceal wall by small tight clusters, nests or cords of tumor cells that exhibit a goblet cell morphology with a small compressed nucleus and conspicuous intracytoplasmic mucin. The coexistence of high-grade adenocarcinoma with GCC has been increasingly recognized as a common finding, which has been called adenocarcinoma ex GCC or mixed GCC-adenocarcinoma. A number of studies have shown that it is the high-grade adenocarcinomatous component that dictates the prognosis. Several histologic classification/grading systems have been proposed, which correlate with overall patient survival. Treatment options are primarily based on tumor stage and the presence or absence of a high-grade adenocarcinomatous component.
杯状细胞类癌（GCC）或杯状细胞癌是一种独特的混合内分泌-外分泌肿瘤，几乎仅见于阑尾。GCC 的标志是阑尾壁的同心性浸润，由小而紧密的簇状、巢状或条索状肿瘤细胞组成，这些细胞具有杯状细胞形态，细胞核小而受压，细胞内有明显的黏蛋白。GCC 伴高级别腺癌的共存已被越来越多地认识到是一种常见的发现，被称为腺癌源于 GCC 或混合 GCC-腺癌。多项研究表明，决定预后的是高级别腺癌成分。已经提出了几种组织学分类/分级系统，这些系统与总体患者生存率相关。治疗选择主要基于肿瘤分期以及是否存在高级别腺癌成分。
