Inhibition of transketolase by N-acetylimidazole.
作者信息
Kuimov A N, Kovina M V, Kochetov G A
机构信息
A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR.
出版信息
Biochem Int. 1988 Sep;17(3):517-21.
PMID:3060120
Abstract
Transketolase from baker's yeast is rapidly inactivated in the presence of N-acetylimidazole. According to kinetic data, acetylation of one amino acid residue of the protein per active site is sufficient for TK* inactivation. The holoenzyme is inhibited more slowly than is apotransketolase. The presence of a tyrosine residue in the enzyme's active site, essential for activity, is suggested.
摘要
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