Sun Shui-Lin, Liu Liang-Ming
Department of Infection, Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Infection, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiaotong University, Shanghai, China.
J Endocrinol. 2019 Mar;240(3):R107-R117. doi: 10.1530/JOE-18-0505.
Urotensin II (UII) is a polypeptide molecule with neurohormone-like activity. It has been confirmed that UII is widely distributed in numerous organs of different animal species from fish to mammals, including humans. The UII receptor is orphan G-protein-coupled receptor 14, also known as UT. The tissue distribution of UII and UT is highly consistent, and their expression may be regulated by autocrine and paracrine mechanisms. In the body, UII has many physiological and pathophysiological activities, such as vasoconstrictor and vasodilatory actions, cell proliferation, pro-fibrosis, neuroendocrine activity, insulin resistance and carcinogenic and inflammatory effects, which have been recognized only in recent years. In fact, UII is involved in the process of inflammatory injury and plays a key role in the onset and development of inflammatory diseases. In this paper, we will review the roles UII plays in inflammatory diseases.
尾加压素II（UII）是一种具有神经激素样活性的多肽分子。现已证实，UII广泛分布于从鱼类到哺乳动物（包括人类）等不同动物物种的众多器官中。UII受体是孤儿G蛋白偶联受体14，也称为UT。UII和UT的组织分布高度一致，它们的表达可能受自分泌和旁分泌机制调节。在体内，UII具有许多生理和病理生理活性，如血管收缩和舒张作用、细胞增殖、促纤维化、神经内分泌活性、胰岛素抵抗以及致癌和炎症效应等，这些作用直到最近几年才被认识到。事实上，UII参与炎症损伤过程，并在炎症性疾病的发生和发展中起关键作用。在本文中，我们将综述UII在炎症性疾病中所起的作用。
