Abd El-Kader Shehab M, Al-Jiffri Osama H
Department of Physical Therapy, Faculty of Applied Medical Sciences, King AbdulazizUniversity, Jeddah, Saudi Arabia.
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Afr Health Sci. 2018 Jun;18(2):417-427. doi: 10.4314/ahs.v18i2.27.
Recently, about 2.35% of the world populations are estimated to be chronically infected with hepatitis C virus (HCV). Previous cohort studies indicated that obesity increases risk of hepatic steatosis and fibrosis in non-diabetic patients with chronic hepatitis C infection due to diminished response to anti-viral therapy and as a result obesity is considered as an important factor in the progression of chronic HCV. However, there is a strong association between BMI and the human immune system among HCV patients.
This study aimed to examine effects of weight reduction program on selected immune parameters among HCV Saudi patients.
One-hundred obese Saudi patients with chronic HCV infection participated in this study, their age ranged from 50-58 years and their body mass index (BMI) ranged from 30-35 kg/m. All Subjects were included in two groups: The first group received weight reduction program in the form of treadmill aerobic exercises in addition to diet control whereas, the second group received no therapeutic intervention. Parameters of CD3, CD4 and CD8 were quantified; Leukocyte, differential counts and BMI were measured before and after 3 months, at the end of the study.
The mean values of BMI, white blood cells, total neutrophil count, monocytes, CD3, CD4 and CD8 were significantly decreased in the training group as a result of weight loss program; however the results of the control group were not significant. Also, there were significant differences between both groups at the end of the study.
Weight loss modulates immune system parameters of patients with HCV.
最近，据估计全球约2.35%的人口慢性感染丙型肝炎病毒（HCV）。先前的队列研究表明，肥胖会增加慢性丙型肝炎感染的非糖尿病患者发生肝脂肪变性和纤维化的风险，原因是对抗病毒治疗的反应减弱，因此肥胖被认为是慢性HCV进展的一个重要因素。然而，在HCV患者中，BMI与人体免疫系统之间存在密切关联。
本研究旨在探讨减肥计划对沙特HCV患者某些免疫参数的影响。
100名患有慢性HCV感染的肥胖沙特患者参与了本研究，他们的年龄在50 - 58岁之间，体重指数（BMI）在30 - 35 kg/m之间。所有受试者被分为两组：第一组接受以跑步机有氧运动加饮食控制形式的减肥计划，而第二组不接受任何治疗干预。对CD3、CD4和CD8参数进行定量；在研究结束时，于3个月前后测量白细胞、分类计数和BMI。
由于减肥计划，训练组的BMI、白细胞、总中性粒细胞计数、单核细胞、CD3、CD4和CD8的平均值显著下降；然而，对照组的结果不显著。此外，在研究结束时两组之间存在显著差异。
体重减轻可调节HCV患者的免疫系统参数。
