Sugimoto Kazuhiro, Hoshino Takehiko, Tamura Akira, Yamazaki Toshiro, Suzuki Susumu, Shimbo Takuro
1Diabetes Center, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama, 963-8558 Japan.
2Department of Physical Training and Science, Ohta Nishinouchi Hospital, Koriyama, Japan.
Diabetol Int. 2018 Mar 24;9(4):243-256. doi: 10.1007/s13340-018-0354-2. eCollection 2018 Oct.
This study aimed at exploring physical fitness including postural stability in relation to peripheral nerve function and clinical neuropathy in patients with type 2 diabetes across a wide range of ages.
We analyzed data collected from 139 patients with type 2 diabetes aged between 19 and 81 years, which included the peripheral nerve conduction parameters and coefficient of variation for normal R-R intervals (CVRR) at rest and during deep breathing. The results of neurological examinations to diagnose probable and confirmed diabetic neuropathies based on the minimal criteria proposed by the Toronto diabetic neuropathy expert group and a battery of physical fitness tests including one-leg standing time with eyes open were also assessed. Multiple linear and logistic regressions were used to estimate the relationships of the physical fitness measures with the parameters of peripheral and cardiac autonomic nerve functions and clinical neuropathies, respectively. Receiver operating characteristic curves were generated to depict the relation between sensitivity and specificity of one-leg standing time for probable and confirmed neuropathies.
After adjustment for age and other potential confounders, one-leg standing time correlated with peripheral and cardiac autonomic nerve functions as well as with probable and confirmed neuropathies. The one-leg standing time of 23 s was found to be 66 and 63% sensitive and 81 and 77% specific for diagnosing probable and confirmed neuropathies, respectively.
Short one-leg standing time was associated with peripheral and cardiac autonomic nerve dysfunction and clinical neuropathy in patients with type 2 diabetes, independent of age.
本研究旨在探讨2型糖尿病患者在广泛年龄范围内与周围神经功能和临床神经病变相关的身体素质，包括姿势稳定性。
我们分析了139例年龄在19至81岁之间的2型糖尿病患者的数据，其中包括周围神经传导参数以及静息和深呼吸时正常R-R间期变异系数（CVRR）。还评估了根据多伦多糖尿病神经病变专家组提出的最低标准进行的神经学检查结果，以诊断可能的和确诊的糖尿病神经病变，以及一系列身体素质测试，包括睁眼单腿站立时间。分别使用多元线性回归和逻辑回归来估计身体素质指标与周围和心脏自主神经功能参数以及临床神经病变之间的关系。生成受试者工作特征曲线以描述单腿站立时间对可能的和确诊的神经病变的敏感性和特异性之间的关系。
在对年龄和其他潜在混杂因素进行调整后，单腿站立时间与周围和心脏自主神经功能以及可能的和确诊的神经病变相关。发现23秒的单腿站立时间对诊断可能的和确诊的神经病变的敏感性分别为66%和63%，特异性分别为81%和77%。
单腿站立时间短与2型糖尿病患者的周围和心脏自主神经功能障碍以及临床神经病变相关，与年龄无关。
