整形与重建外科中的可注射生物材料：现状综述
Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status.
作者信息
Cho Ki-Hyun, Uthaman Saji, Park In-Kyu, Cho Chong-Su
机构信息
1Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH 44195 USA.
2Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea.
出版信息
Tissue Eng Regen Med. 2018 Sep 1;15(5):559-574. doi: 10.1007/s13770-018-0158-2. eCollection 2018 Oct.
BACKGROUND
Injectable biomaterials have attracted increasing attention for volume restoration and tissue regeneration. The main aim of this review is to discuss the current status of the injectable biomaterials for correction of tissue defects in plastic and reconstructive surgery.
METHODS
Requirements of injectable biomaterials, mechanism of in situ gelation, characteristics, and the combinational usage of adipose-derived stem cells (ADSCs) and growth factors were reviewed.
RESULTS
The ideal injectable biomaterials should be biocompatible, non-toxic, easy to use, and cost-effective. Additionally, it should possess adequate mechanical properties and stability. In situ gelation method includes physical, chemical, enzymatic and photo-initiated methods. Natural and synthetic biomaterials carry their pros and cons due to their inherent properties. The combined use of ADSCs and growth factors provides enhanced potential for adipose tissue regeneration.
CONCLUSIONS
The usage of injectable biomaterials has been increasing for the tissue restoration and regeneration. The future of incorporating ADSCs and growth factors into the injectable biomaterials is promising.
背景
可注射生物材料在体积恢复和组织再生方面越来越受到关注。本综述的主要目的是讨论可注射生物材料在整形和重建手术中修复组织缺损的现状。
方法
综述了可注射生物材料的要求、原位凝胶化机制、特性以及脂肪干细胞（ADSCs）与生长因子的联合应用。
结果
理想的可注射生物材料应具有生物相容性、无毒、易于使用且具有成本效益。此外，它应具备足够的机械性能和稳定性。原位凝胶化方法包括物理、化学、酶促和光引发方法。天然和合成生物材料因其固有特性各有优缺点。ADSCs与生长因子的联合使用为脂肪组织再生提供了更大的潜力。
结论
可注射生物材料在组织修复和再生中的应用一直在增加。将ADSCs和生长因子纳入可注射生物材料的前景广阔。
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