Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Medical Center, 56 Dalseung-ro, Joong-gu, Daegu, 41931, Republic of Korea.
J Anesth. 2019 Apr;33(2):209-215. doi: 10.1007/s00540-018-2600-y. Epub 2019 Jan 2.
Tracheal intubation for general anesthesia causes postoperative sore throat. The purpose of this study was to evaluate the effect of sevoflurane and desflurane on prevalence of postoperative sore throat in patients after general anesthesia.
Ninety-six patients scheduled for orthopedic lower extremity surgery under general anesthesia were assigned to sevoflurane group or desflurane group. In the sevoflurane group (n = 48), sevoflurane was used as a maintenance anesthetic agent. In the desflurane group (n = 48), desflurane was used. Prevalence of sore throat, number of patients with rescue analgesics, and analgesics requirements were evaluated.
The overall prevalence of postoperative sore throat in the sevoflurane group was lower than that in the desflurane group [21 (44%) vs. 32 (67%), p = 0.024]. The prevalence of sore throat at postoperative 4 h in the sevoflurane group was lower than that in the desflurane group [6 (13%) vs. 18 (38%), p = 0.005]. The number of patients requiring rescue analgesics was lower in the sevoflurane group [25 (52%) vs. 36 (75%), p = 0.020]. The requirement of diclofenac was also lower in the sevoflurane group (30 ± 37 mg vs. 47 ± 40 mg, p = 0.031).
We have shown that sevoflurane was associated with less frequent sore throat than desflurane in patients undergoing orthopedic lower extremity surgery.
全身麻醉下进行气管插管会导致术后咽痛。本研究旨在评估七氟醚和地氟醚对全麻后患者术后咽痛发生率的影响。
96 例行择期下肢骨科手术的患者被分为七氟醚组或地氟醚组。七氟醚组（n=48）以七氟醚作为维持麻醉剂，地氟醚组（n=48）以地氟醚作为维持麻醉剂。评估咽痛发生率、需要使用解救镇痛药物的患者数量和镇痛药物需求。
七氟醚组的术后咽痛总发生率低于地氟醚组[21（44%）比 32（67%），p=0.024]。七氟醚组术后 4 小时咽痛发生率低于地氟醚组[6（13%）比 18（38%），p=0.005]。需要使用解救镇痛药物的患者数量在七氟醚组中较低[25（52%）比 36（75%），p=0.020]。七氟醚组的双氯芬酸需求量也较低（30±37mg 比 47±40mg，p=0.031）。
与地氟醚相比，七氟醚可降低行下肢骨科手术患者的咽痛发生率。
