Department of Anesthesiology and Reanimation, Konya University, Meram Medical Faculty, Konya, Turkey.
Anesthesiology. 2012 Sep;117(3):512-8. doi: 10.1097/ALN.0b013e3182639d5f.
Postoperative sore throat (POST) is an undesirable complaint after orotracheal intubation. Magnesium is a noncompetitive N-methyl-D-aspartate receptor antagonist thought to be involved in the modulation of pain. The present study aimed to investigate the effect of preoperative administration of oral magnesium lozenge on POST.
Seventy patients undergoing orthopedic surgery were randomly allocated into two groups, to either receive placebo (control) or magnesium lozenges (magnesium) to be dissolved by sucking 30 min preoperatively. Patients were assessed for incidence and severity (four-point scale, 0-3) of POST at 0, 2, 4, and 24 h postoperatively. The primary outcome was sore throat at 4 h after surgery. The secondary outcome was the severity of POST at four evaluation time-points postoperatively.
The incidence of POST at 4 h was higher in control group than in magnesium group (95% CI: 26%, 14-42%; P=0.032). The highest incidence of POST occurred at the second hour after surgery, with the rate of 23% in the magnesium group and 57% in the control group (95% CI: 34%, 20-51%; P=0.007). The severity of POST was significantly lower in the magnesium group at 0 (P=0.007) and 2 h (P=0.002). The incidences of POST at 0 and 24 h and severity scores at 4 and 24 h were not significantly different between the groups.
The administration of magnesium lozenge 30 min preoperatively is effective to reduce both incidence and severity of POST in the immediate postoperative period.
术后咽喉痛（POST）是经口气管插管后一种不理想的主诉。镁是一种非竞争性 N-甲基-D-天冬氨酸受体拮抗剂，被认为参与疼痛的调节。本研究旨在探讨术前口服镁含片对 POST 的影响。
70 例行骨科手术的患者被随机分为两组，分别接受安慰剂（对照组）或镁含片（镁组），在术前 30 分钟通过吸吮溶解。患者在术后 0、2、4 和 24 小时评估 POST 的发生率和严重程度（四点量表，0-3 分）。主要结局是术后 4 小时的咽喉痛。次要结局是术后四个评估时间点的 POST 严重程度。
对照组术后 4 小时 POST 的发生率高于镁组（95%可信区间：26%，14-42%；P=0.032）。POST 的最高发生率发生在手术后第二小时，镁组的发生率为 23%，对照组为 57%（95%可信区间：34%，20-51%；P=0.007）。镁组在 0 小时（P=0.007）和 2 小时（P=0.002）时 POST 的严重程度显著降低。两组在术后 0 小时和 24 小时的 POST 发生率以及术后 4 小时和 24 小时的严重程度评分均无显著差异。
术前 30 分钟给予镁含片可有效降低术后即刻 POST 的发生率和严重程度。
