Department of Children Rehabilitation Medicine, Fifth Affiliated Hospital of Zhengzhou University, No. 3 rehabilitation Street, 27 District, Zhengzhou, 450052, Henan, China.
Laboratory, Henan Province Hospital of Traditional China Medicine, Zhengzhou, 450052, Henan, China.
J Mol Neurosci. 2019 Feb;67(2):305-311. doi: 10.1007/s12031-018-1239-3. Epub 2019 Jan 2.
To study the clinical effectiveness and mechanism of GM1 acupoint injection therapy on mental retardation for children with cerebral palsy (CP). A total of 90 children with CP were divided into acupoint injection group (group A), subcutaneous injection group (group B), and control group (group C). Another 30 healthy children were set as a healthy control group (group D). The Mental Developmental Index (MDI), Psychomotor Developmental Index (PDI), and hemodynamic parameters in the cerebral arteries were measured before and after treatment. After three treatment courses, the MDI and PDI in groups A, B, and C were increased, and the increase in group A was most obvious (P < 0.05). Peak systolic velocity, mean velocity, and end-diastolic velocity were also elevated in group A, and after three treatment courses, resistance index decreased with a statistical significance (P < 0.05). However, there were no significant changes in groups B and C (P > 0.05). For all groups, neuron-specific enolase levels decreased and total superoxide dismutase increased after treatment. Acupoint injection therapy combined with conventional rehabilitation therapy demonstrated significant effects on cerebral hemodynamic conditions for children with CP.
研究穴位注射 GM1 治疗脑性瘫痪（CP）儿童智力低下的临床疗效及作用机制。方法：将 90 例 CP 患儿分为穴位注射组（A 组）、皮下注射组（B 组）和对照组（C 组），另取 30 例健康儿童为健康对照组（D 组）。治疗前后分别测定各组患儿的精神发育指数（MDI）、运动发育指数（PDI）和脑动脉血流动力学参数。治疗 3 个疗程后，A、B、C 组 MDI、PDI 均升高，其中 A 组升高最明显（P<0.05），A 组的收缩期峰值流速、平均流速、舒张末期流速也均升高，且治疗 3 个疗程后阻力指数降低，差异有统计学意义（P<0.05），而 B、C 组差异无统计学意义（P>0.05）。所有患儿神经元特异性烯醇化酶水平降低，总超氧化物歧化酶升高。结论：穴位注射 GM1 联合常规康复疗法对 CP 患儿脑血流动力学有显著改善作用。
