Schliamser S E, Bolander H, Kourtopoulos H, Sigaard J, Norrby S R
Department of Infectious Diseases, University of Umeå, Sweden.
J Antimicrob Chemother. 1988 Oct;22(4):521-8. doi: 10.1093/jac/22.4.521.
The neurotoxic potential of benzylpenicillin administered intravenously as a continuous infusion was studied in rabbits with experimental Escherichia coli meningitis. As controls a group of rabbits was injected with saline into the cisterna magna. The concentrations of benzylpenicillin in serum, CSF and brain tissue fluid were studied at onset of epileptogenic electroencephalographic activity (thirteen rabbits) or convulsions (ten rabbits), with a previously developed method for neurotoxicity studies. E. coli meningitis did not increase the neurotoxicity of benzylpenicillin, despite high concentrations of the drug in both CSF and brain tissue fluid. The intracisternal injection of saline in the control group produced slight pleocytosis in some rabbits indicating some degree of damage of the blood-CSF barrier.
在患有实验性大肠杆菌脑膜炎的兔子中，研究了静脉持续输注苄青霉素的神经毒性潜力。作为对照，一组兔子经枕大池注射生理盐水。采用先前开发的神经毒性研究方法，在癫痫样脑电图活动发作时（13只兔子）或惊厥发作时（10只兔子），研究血清、脑脊液和脑组织液中苄青霉素的浓度。尽管脑脊液和脑组织液中药物浓度很高，但大肠杆菌脑膜炎并未增加苄青霉素的神经毒性。对照组经枕大池注射生理盐水后，部分兔子出现轻微的细胞增多，表明血脑脊液屏障有一定程度的损伤。
