Department of Rehabilitation, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 45000, China.
Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 45000, China.
Biosci Rep. 2020 May 29;40(5). doi: 10.1042/BSR20193917.
To investigate the possible role of superoxide dismutases (SODs) in the development of benign paroxysmal positional vertigo (BPPV) and recurrence events in a 1-year follow-up study.
This was a prospective one-center study. A total of 204 patients with BPPV and 120 age-and sex matched healthy subjects were included. The levels of SOD between patients and control cases were compared. The levels of SOD between posterior semicircular canal (PSC) and horizontal semicircular canal (HSC) were also compared. In the 1-year follow-up, recurrence events were confirmed. The influence of SOD levels on BPPV and recurrent BPPV were performed by binary logistic regression analysis.
The serum levels of SOD in patients with BPPV were lower than in those control cases (P<0.001). Levels of SOD did not differ in patients with PSC and HSC (P=0.42). As a categorical variable, for per interquartile range (IQR) increment of serum level of SOD, the unadjusted and adjusted risks of BPPV would be decreased by 72% (with the odds ratio [OR] of 0.28 [95% confidence interval (CI): 0.21-0.37], P<0.001) and 43% (0.57 [0.42-0.69], P<0.001), respectively. Recurrent attacks of BPPV were reported in 50 patients (24.5%). Patients with recurrent BPPV had lower levels of SOD than in patients without (P<0.001). For per IQR increment of serum level of SOD, the unadjusted and adjusted risks of BPPV would be decreased by 51% (with the OR of 0.49 [95% CI: 0.36-0.68], P<0.001) and 24% (0.76 [0.60-0.83], P<0.001), respectively.
Reduced serum levels of SOD were associated with higher risk of BPPV and BPPV recurrence events.
通过为期 1 年的随访研究，探讨超氧化物歧化酶（SOD）在良性阵发性位置性眩晕（BPPV）发展和复发事件中的可能作用。
这是一项前瞻性单中心研究。共纳入 204 例 BPPV 患者和 120 例年龄和性别匹配的健康对照者。比较患者和对照组之间的 SOD 水平。还比较了后半规管（PSC）和水平半规管（HSC）之间的 SOD 水平。在 1 年的随访期间，确认了复发事件。通过二元逻辑回归分析，研究 SOD 水平对 BPPV 和复发性 BPPV 的影响。
BPPV 患者的血清 SOD 水平低于对照组（P<0.001）。PSC 和 HSC 患者的 SOD 水平无差异（P=0.42）。作为一个分类变量，血清 SOD 水平每增加一个四分位间距（IQR），未经调整和调整后的 BPPV 风险分别降低 72%（比值比 [OR]为 0.28[95%置信区间（CI）：0.21-0.37]，P<0.001）和 43%（0.57[0.42-0.69]，P<0.001）。50 例（24.5%）患者出现 BPPV 复发。复发 BPPV 患者的 SOD 水平低于无复发患者（P<0.001）。血清 SOD 水平每增加一个 IQR，未经调整和调整后的 BPPV 风险分别降低 51%（OR 为 0.49[95%CI：0.36-0.68]，P<0.001）和 24%（0.76[0.60-0.83]，P<0.001）。
血清 SOD 水平降低与 BPPV 及 BPPV 复发事件风险增加相关。
