伤口渗出液 CXCL6：糖尿病足溃疡伤口愈合的潜在生物标志物。
Wound exudate CXCL6: a potential biomarker for wound healing of diabetic foot ulcers.
机构信息
Department of Pain, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430021, PR China.
Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430021, PR China.
出版信息
Biomark Med. 2019 Feb;13(3):167-174. doi: 10.2217/bmm-2018-0339. Epub 2019 Jan 3.
AIM
The aim of this study was to investigate the relationship between CXCL-6 levels in wound exudates and healing of diabetic foot ulcers (DFU).
MATERIALS & METHODS: One hundred patients with neuropathic DFU were recruited. Wound exudate CXCL-6 levels were measured by enzyme-linked immunosorbent assay. Patients were followed for 24 weeks and divided into rapidly healing and nonhealing groups.
RESULTS
Compared with the NH group, the mean CXCL-6 levels in the wound exudates of the rapidly healing group were significantly higher. After adjusting for traditional risk factors, wound exudate CXCL-6 levels were still significantly associated with wound healing.
CONCLUSION
CXCL6 is an independent predictor of wound healing in DFU patients and may be a potentially novel therapeutic target for the treatment of DFU.
目的
本研究旨在探讨创面渗液中 CXCL-6 水平与糖尿病足溃疡（DFU）愈合的关系。
材料与方法
共纳入 100 例伴有神经病变的 DFU 患者。采用酶联免疫吸附试验检测创面渗液中 CXCL-6 水平。对患者进行 24 周随访，并分为快速愈合组和非愈合组。
结果
与 NH 组相比，快速愈合组创面渗液中 CXCL-6 水平明显更高。在调整传统危险因素后，创面渗液 CXCL-6 水平仍与创面愈合显著相关。
结论
CXCL6 是 DFU 患者创面愈合的独立预测因子，可能是治疗 DFU 的潜在新靶点。
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