中文译文：糖尿病前期和 2 型糖尿病中的趋化因子：一项荟萃分析。
Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis.
机构信息
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, China.
出版信息
Front Immunol. 2021 May 13;12:622438. doi: 10.3389/fimmu.2021.622438. eCollection 2021.
BACKGROUND
A growing number of studies found inconsistent results on the role of chemokines in the progression of type 2 diabetes (T2DM) and prediabetes (PDM). The purpose of this meta-analysis was to summarize the results of previous studies on the association between the chemokines system and T2DM/PDM.
METHODS
We searched in the databases, PubMed, Web of Science, Embase and Cochrane Library, for eligible studies published not later than March 1, 2020. Data extraction was performed independently by 2 reviewers, on a standardized, prepiloted form. Group differences in chemokines concentrations were summarized using the standardized mean difference (SMD) with a 95% confidence interval (CI), calculated by performing a meta-analysis using the random-effects model.
RESULTS
We identified 98 relevant studies that investigated the association between 32 different chemokines and T2DM/PDM. Altogether, these studies involved 14,708 patients and 14,574 controls. Results showed that the concentrations of CCL1, CCL2, CCL4, CCL5, CCL11, CXCL8, CXCL10 and CX3CL1 in the T2DM patients were significantly higher than that in the controls, while no difference in these concentrations was found between the PDM patients and controls.
CONCLUSION
Progression of T2DM may be associated with elevated concentrations of chemokines.
META-ANALYSIS REGISTRATION: PROSPERO, identifier CRD42019148305.
背景
越来越多的研究发现趋化因子在 2 型糖尿病（T2DM）和糖尿病前期（PDM）进展中的作用结果不一致。本荟萃分析的目的是总结趋化因子系统与 T2DM/PDM 之间关联的先前研究结果。
方法
我们在数据库 PubMed、Web of Science、Embase 和 Cochrane Library 中搜索了截至 2020 年 3 月 1 日发表的合格研究。由 2 名审阅者独立使用标准化、预编制表格进行数据提取。使用标准化均数差（SMD）和 95%置信区间（CI）汇总趋化因子浓度的组间差异，使用随机效应模型进行荟萃分析计算。
结果
我们确定了 98 项相关研究，这些研究调查了 32 种不同趋化因子与 T2DM/PDM 之间的关联。这些研究总共涉及 14708 名患者和 14574 名对照。结果表明，T2DM 患者的 CCL1、CCL2、CCL4、CCL5、CCL11、CXCL8、CXCL10 和 CX3CL1 浓度明显高于对照组，而 PDM 患者与对照组之间这些浓度没有差异。
结论
T2DM 的进展可能与趋化因子浓度升高有关。
荟萃分析注册
PROSPERO，标识符 CRD42019148305。
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