Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Neuron. 2019 Jan 2;101(1):3-5. doi: 10.1016/j.neuron.2018.12.015.
Hypernatremia is known to elicit a rise in sympathetic tone and blood pressure. In this issue of Neuron, Nomura et al. (2018) now show that this is mediated via the organum vasculosum laminae terminalis (OVLT). Na activates OVLT neurons via a paracrine mechanism involving sodium channel Na expressed by astrocytes and the ependyma.
高钠血症已知会引起交感神经张力和血压升高。在本期《神经元》杂志中，野村等人（2018）现在表明，这是通过血管终板器官（OVLT）介导的。钠通过涉及星形胶质细胞和室管膜表达的钠通道 Na 的旁分泌机制激活 OVLT 神经元。
