OVLT 通过检测钠来调节交感神经紧张度。
Sodium Is Detected by the OVLT to Regulate Sympathetic Tone.
机构信息
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
出版信息
Neuron. 2019 Jan 2;101(1):3-5. doi: 10.1016/j.neuron.2018.12.015.
Abstract
Hypernatremia is known to elicit a rise in sympathetic tone and blood pressure. In this issue of Neuron, Nomura et al. (2018) now show that this is mediated via the organum vasculosum laminae terminalis (OVLT). Na activates OVLT neurons via a paracrine mechanism involving sodium channel Na expressed by astrocytes and the ependyma.
摘要
高钠血症已知会引起交感神经张力和血压升高。在本期《神经元》杂志中，野村等人（2018）现在表明，这是通过血管终板器官（OVLT）介导的。钠通过涉及星形胶质细胞和室管膜表达的钠通道 Na 的旁分泌机制激活 OVLT 神经元。
相似文献
1
Sodium Is Detected by the OVLT to Regulate Sympathetic Tone.OVLT 通过检测钠来调节交感神经紧张度。
Neuron. 2019 Jan 2;101(1):3-5. doi: 10.1016/j.neuron.2018.12.015.
2
Na-positive glial cells in the organum vasculosum laminae terminalis produce epoxyeicosatrienoic acids to induce water intake in response to increases in [Na] in body fluids.终板器血管周围器官中的 Na 阳性神经胶质细胞产生环氧二十碳三烯酸，以响应体液中 [Na] 的增加诱导水的摄入。
Neurosci Res. 2020 May;154:45-51. doi: 10.1016/j.neures.2019.05.006. Epub 2019 May 28.
3
[Na] Increases in Body Fluids Sensed by Central Na Induce Sympathetically Mediated Blood Pressure Elevations via H-Dependent Activation of ASIC1a.[钠]中枢钠离子感受器感知到的体液增加通过 H 依赖性激活 ASIC1a 引起交感神经介导的血压升高。
Neuron. 2019 Jan 2;101(1):60-75.e6. doi: 10.1016/j.neuron.2018.11.017. Epub 2018 Nov 29.
4
NaCl and osmolarity produce different responses in organum vasculosum of the lamina terminalis neurons, sympathetic nerve activity and blood pressure.NaCl 和渗透压会对终板血管器神经元、交感神经活动和血压产生不同的反应。
J Physiol. 2017 Sep 15;595(18):6187-6201. doi: 10.1113/JP274537. Epub 2017 Aug 2.
5
Activation of the Organum Vasculosum of the Lamina Terminalis Produces a Sympathetically Mediated Hypertension.终板血管器官的激活会导致交感神经介导的高血压。
Hypertension. 2022 Jan;79(1):139-149. doi: 10.1161/HYPERTENSIONAHA.121.18117. Epub 2021 Nov 23.
6
SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na] sensor for the control of water intake.终板器血管器官中的 SLC9A4 是一种 [Na] 传感器，可控制水的摄入。
Pflugers Arch. 2020 May;472(5):609-624. doi: 10.1007/s00424-020-02389-y. Epub 2020 May 6.
7
Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood Pressure.终板血管器可检测氯化钠以升高交感神经活动和血压。
Hypertension. 2017 Jan;69(1):163-170. doi: 10.1161/HYPERTENSIONAHA.116.08372. Epub 2016 Nov 28.
8
Anatomical organization of the rat organum vasculosum laminae terminalis.大鼠终板血管器的解剖结构
Am J Physiol Regul Integr Comp Physiol. 2015 Aug 15;309(4):R324-37. doi: 10.1152/ajpregu.00134.2015. Epub 2015 May 27.
9
Brain sodium sensing for regulation of thirst, salt appetite, and blood pressure.脑钠素感应调节口渴、盐欲和血压。
Physiol Rep. 2024 Mar;12(5):e15970. doi: 10.14814/phy2.15970.
10
Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia.盐依赖性神经源性高血压的潜在机制：高钠血症对终板血管器神经元的细胞自主激活。
Hypertension. 2017 Jan;69(1):20-22. doi: 10.1161/HYPERTENSIONAHA.116.08470. Epub 2016 Nov 28.
引用本文的文献
1
Central respiratory chemoreception.中枢呼吸化学感受性。
Handb Clin Neurol. 2022;188:37-72. doi: 10.1016/B978-0-323-91534-2.00007-2.
2
Bacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of Hypertension the Gut.细菌诱导的血压降低：肠道治疗高血压的机制
Front Cardiovasc Med. 2021 Aug 13;8:721393. doi: 10.3389/fcvm.2021.721393. eCollection 2021.
3
Structure and Function of the Blood-Brain Barrier (BBB).血脑屏障（BBB）的结构和功能。
Handb Exp Pharmacol. 2022;273:3-31. doi: 10.1007/164_2020_404.
本文引用的文献
1
[Na] Increases in Body Fluids Sensed by Central Na Induce Sympathetically Mediated Blood Pressure Elevations via H-Dependent Activation of ASIC1a.[钠]中枢钠离子感受器感知到的体液增加通过 H 依赖性激活 ASIC1a 引起交感神经介导的血压升高。
Neuron. 2019 Jan 2;101(1):60-75.e6. doi: 10.1016/j.neuron.2018.11.017. Epub 2018 Nov 29.
2
Lactate in the brain: from metabolic end-product to signalling molecule.脑内乳酸：从代谢终产物到信号分子。
Nat Rev Neurosci. 2018 Apr;19(4):235-249. doi: 10.1038/nrn.2018.19. Epub 2018 Mar 8.
3
NaCl and osmolarity produce different responses in organum vasculosum of the lamina terminalis neurons, sympathetic nerve activity and blood pressure.NaCl 和渗透压会对终板血管器神经元、交感神经活动和血压产生不同的反应。
J Physiol. 2017 Sep 15;595(18):6187-6201. doi: 10.1113/JP274537. Epub 2017 Aug 2.
4
Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood Pressure.终板血管器可检测氯化钠以升高交感神经活动和血压。
Hypertension. 2017 Jan;69(1):163-170. doi: 10.1161/HYPERTENSIONAHA.116.08372. Epub 2016 Nov 28.
5
Thirst neurons anticipate the homeostatic consequences of eating and drinking.口渴神经元能预测进食和饮水对体内平衡的影响。
Nature. 2016 Sep 29;537(7622):680-684. doi: 10.1038/nature18950. Epub 2016 Aug 3.
6
Proton detection and breathing regulation by the retrotrapezoid nucleus.后梯形核的质子检测与呼吸调节
J Physiol. 2016 Mar 15;594(6):1529-51. doi: 10.1113/JP271480. Epub 2016 Feb 19.
7
Cerebrospinal Fluid Hypernatremia Elevates Sympathetic Nerve Activity and Blood Pressure via the Rostral Ventrolateral Medulla.脑脊液高钠血症通过延髓头端腹外侧区升高交感神经活性和血压。
Hypertension. 2015 Dec;66(6):1184-90. doi: 10.1161/HYPERTENSIONAHA.115.05936. Epub 2015 Sep 28.
8
Dietary sodium and health: more than just blood pressure.膳食钠与健康：不止关乎血压。
J Am Coll Cardiol. 2015 Mar 17;65(10):1042-50. doi: 10.1016/j.jacc.2014.12.039.
9
Intracarotid hypertonic sodium chloride differentially modulates sympathetic nerve activity to the heart and kidney.高渗氯化钠经颈动脉内给药可调节心脏和肾脏的交感神经活性。
Am J Physiol Regul Integr Comp Physiol. 2014 Apr 15;306(8):R567-75. doi: 10.1152/ajpregu.00460.2013. Epub 2014 Feb 12.
10
Na(x) channel involved in CNS sodium-level sensing.参与中枢神经系统钠水平感知的钠（x）通道。
Nat Neurosci. 2002 Jun;5(6):511-2. doi: 10.1038/nn0602-856.
Zotero 插件