海洋来源真菌青霉 YPGA11 中两个新的倍半萜和两个新的单萜。
Two new meroterpenoids and two new monoterpenoids from the deep sea-derived fungus Penicillium sp. YPGA11.
机构信息
Pharmaceutical College, Henan University, Kaifeng 475004, People's Republic of China; College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, People's Republic of China.
出版信息
Fitoterapia. 2019 Mar;133:120-124. doi: 10.1016/j.fitote.2018.12.022. Epub 2018 Dec 31.
Twelve terpenoids, including two new 3,5-dimethylorsellinic acid-based meroterpenoids (1 and 2) and two new monoterpenoids (11 and 12), were obtained from the deep-sea fungus Penicillium sp. YPGA11. Their structures were determined by extensive analyses of spectroscopic data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental and calculated ECD spectra. Compounds 1 and 2, bearing a 23-aldehyde or 23-carboxylic acid group, were rarely found in compounds with similar carbon skeleton. All compounds but 11 were evaluated for inhibitory effects towards nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compound 9 exhibited significant inhibitory effects with an IC value of 7.58 μM, being comparable to the positive control, quercetin (10.97 μM).
从深海真菌青霉属 YPGA11 中分离得到了 12 个萜类化合物，包括两个新的 3,5-二甲基奥尔酸基混合萜类化合物（1 和 2）和两个新的单萜类化合物（11 和 12）。通过对光谱数据的广泛分析确定了它们的结构，通过比较实验和计算的 ECD 光谱确定了 1 和 2 的绝对构型。化合物 1 和 2 带有 23-醛基或 23-羧酸基，在具有相似碳骨架的化合物中很少见。除了 11 之外，所有化合物都评估了对 RAW 264.7 巨噬细胞中脂多糖诱导的一氧化氮生成的抑制作用。化合物 9 表现出显著的抑制作用，IC 值为 7.58 μM，与阳性对照槲皮素（10.97 μM）相当。
Zotero 插件