一株青霉JX4 中五个新的三烯衍生物
Five New Triene Derivatives from the Fungus Penicillium herquei JX4.
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, P. R. China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, P. R. China.
出版信息
Chem Biodivers. 2021 May;18(5):e2100027. doi: 10.1002/cbdv.202100027. Epub 2021 Apr 15.
Five undescribed triene derivatives, pinophols B-F (2-6), together with one known compound, pinophol A (1), were obtained from the mangrove endophytic fungus Penicillium herquei JX4. The structures of compounds 1-6 were elucidated using IR, HR-ESI-MS, and NMR methods. The absolute configurations of compounds 1-6 were confirmed by comparing their experimental or calculated ECD spectra. Pinophols C and D (3 and 4) showed inhibitory activities against LPS-induced NO production.
从红树林内生真菌 Penicillium herquei JX4 中分离得到五个未被描述的三烯衍生物，分别为 pinophols B-F（2-6），以及一个已知化合物 pinophol A（1）。采用 IR、HR-ESI-MS 和 NMR 等方法鉴定了化合物 1-6 的结构。通过比较化合物 1-6 的实验或计算 ECD 光谱，确定了它们的绝对构型。化合物 3 和 4（pinophols C 和 D）对 LPS 诱导的 NO 产生具有抑制活性。
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