从内生真菌青霉属 purpurogenum 中分离得到的两种新型 Nor-seco-Isodhilarane 型倍半萜。
Two New Nor-seco-Isodhilarane-Type Meroterpenoids from the Endophytic Fungus Penicillium purpurogenum.
机构信息
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Wuya college of innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Key Laboratory of Chinese internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
出版信息
Chem Biodivers. 2022 Jul;19(7):e202200403. doi: 10.1002/cbdv.202200403. Epub 2022 Jun 8.
Two new nor-seco isodhilarane meroterpenoids (NSIMs), purpurogenolides F (1) and G (2), along with three known meroterpenoid analogs (3-5), were isolated from the cultures of an endophytic fungus, Penicillium purpurogenum. Structures and absolute configurations of the new NSIMs were determined based on extensive spectroscopic data analyses, including HR-ESI-MS, UV, IR, NMR chemical shift calculations together with DP4+ probability analysis, as well as ECD calculations. All the isolated meroterpenoids were assessed for their anti-inflammatory activities, and compound 4 exhibited moderate inhibitory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW 264.7 cells with an IC value of 20.85±2.31 μM.
从内生真菌青霉（Penicillium purpurogenum）的培养物中分离得到了两种新的诺-裂环异海松烷型倍半萜（NSIMs），即紫罗酮内酯 F（1）和 G（2），以及三种已知的倍半萜类似物（3-5）。根据广泛的光谱数据分析，包括高分辨电喷雾质谱（HR-ESI-MS）、紫外（UV）、红外（IR）、NMR 化学位移计算以及 DP4+概率分析和 ECD 计算，确定了新 NSIMs 的结构和绝对构型。所有分离出的倍半萜均进行了抗炎活性评估，化合物 4 对脂多糖（LPS）诱导的 RAW 264.7 细胞中一氧化氮（NO）的产生具有中等抑制活性，IC 值为 20.85±2.31 μM。
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