Phillips R E, Smith M C, Thoma R J
Intermedics, Inc., Angleton, Texas 77515.
J Biomater Appl. 1988 Oct;3(2):207-27. doi: 10.1177/088532828800300204.
Three mechanisms have been described which explain various observed interactions between polyurethane chemistry and body chemistry. These include calcification, environmental stress cracking, and chain scission. Each may result in implant device failure, and each appears to involve metal ion complexation as a key parameter. Continued expansion of polyurethane into implantable product applications will require further clarification of the effect of each of these interactions on long-term product performance. It is believed that design considerations and polymer modifications will help control the effects of each of the interactions and will result in new and improved polyurethane implant products.
已经描述了三种机制，它们解释了聚氨酯化学与人体化学之间观察到的各种相互作用。这些机制包括钙化、环境应力开裂和链断裂。每种机制都可能导致植入装置失效，并且每种机制似乎都涉及金属离子络合作为关键参数。聚氨酯在可植入产品应用中的持续扩展将需要进一步阐明这些相互作用中的每一种对长期产品性能的影响。据信，设计考虑因素和聚合物改性将有助于控制每种相互作用的影响，并将产生新的和改进的聚氨酯植入产品。
