Bartoszuk U, Keene B W, Baron Toaldo M, Pereira N, Summerfield N, Novo Matos J, Glaus T M
Division of Cardiology, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zürich, Winterthurerstrasse 260, CH-8057 Zürich, Switzerland.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Dr. Raleigh, NC 27607, USA.
Vet J. 2019 Jan;243:21-25. doi: 10.1016/j.tvjl.2018.11.005. Epub 2018 Nov 12.
Arrhythmias can complicate cardiac disease in cats and are a potential cause of sudden death. The aim of this study was to evaluate the presence and nature of cardiac arrhythmias, and the potential correlation between plasma serum troponin I (cTnI) concentrations and the presence or severity of arrhythmias in cats with decompensated (dHCM) and compensated hypertrophic cardiomyopathy (cHCM). Forty one client-owned cats were studied: 16 with cHCM, 15 with dHCM and 10 healthy control cats. Physical examination, echocardiography, cTnI and 24-h Holter recordings were obtained in all cats and thoracic radiographs in cats with dHCM. Cats in both HCM groups were followed for 1 year after their initial Holter examination. The median (range) number of ventricular premature complexes (VPCs) over 24h was 867 (1-35,160) in cats with dHCM, 431 (0-18,919) in cats with cHCM and 2 (0-13) in healthy control cats. The median number of episodes of ventricular tachycardia (VTach) was 0 (0-1497) in dHCM and 0.5 (0-91) in cats with cHCM. The number of VPCs, VTach episodes and heart rate was not different between the HCM groups. Plasma serum troponin I was highest in the cats with dHCM, but there was no correlation between cTnI concentration and the number of arrhythmias. Thirteen of 31 cats with HCM died, but an association with the presence and complexity of ventricular arrhythmias was not observed. Compared to healthy cats, ventricular arrhythmias were common in cats with cHCM and dHCM, but neither presence nor complexity of arrhythmias could be linked to prognosis.
心律失常会使猫的心脏疾病复杂化，并且是猝死的一个潜在原因。本研究的目的是评估猫心律失常的存在情况和性质，以及血浆血清肌钙蛋白I（cTnI）浓度与失代偿性肥厚型心肌病（dHCM）和代偿性肥厚型心肌病（cHCM）猫心律失常的存在或严重程度之间的潜在相关性。对41只客户拥有的猫进行了研究：16只患有cHCM，15只患有dHCM，10只健康对照猫。对所有猫进行了体格检查、超声心动图检查、cTnI检测和24小时动态心电图记录，对患有dHCM的猫进行了胸部X光检查。两个HCM组的猫在首次动态心电图检查后随访1年。dHCM猫24小时内室性早搏（VPC）的中位数（范围）为867（1-35,160），cHCM猫为431（0-18,919），健康对照猫为2（0-13）。室性心动过速（VTach）发作的中位数在dHCM猫中为0（0-1497），在cHCM猫中为0.5（0-91）。HCM组之间的VPC数量、VTach发作次数和心率没有差异。血浆血清肌钙蛋白I在dHCM猫中最高，但cTnI浓度与心律失常数量之间没有相关性。31只患有HCM的猫中有13只死亡，但未观察到与室性心律失常的存在和复杂性有关联。与健康猫相比，cHCM和dHCM猫中室性心律失常很常见，但心律失常的存在或复杂性均与预后无关。
