College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China.
Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:402-411. doi: 10.1016/j.msec.2018.11.047. Epub 2018 Nov 27.
Intensive efforts have been employed in modifying biomedical membranes. Among them, blending is recognized as a simple method. However, the conventional blending materials commonly lead to an insufficient modification, which is mainly caused by the poor miscibility between the blending materials and the matrixes, the elution of the hydrophilic materials from the matrixes during the use and storage, and the insufficient surface enrichment of the blending materials. Aiming to solve the abovementioned disadvantages, we developed novel polyethersulfone/poly(acrylic acid-co-N-vinyl-2-pyrrolidone) networked submicrogels (PES/P(AA-VP) NSs), which were blended with PES to enhance the antifouling properties, antibacterial adhesion and haemocompatible properties of PES membranes. As results, the PES/P(AA-VP) NSs showed good miscibility with the PES matrix, and hydrophilic submicrogels would enrich onto the membrane surface during the phase inversion process due to the surface segregation. The entanglement between the PES matrix and the networked submicrogels would effectively limit the elution of the submicrogels. In conclusion, the modified PES membranes prepared by blending with the PES/P(AA-VP) NSs might draw great attention for the application in haemodialysis fields.
人们在对生物医学膜进行改性方面付出了巨大努力。其中，共混被认为是一种简单的方法。然而，传统的共混材料通常导致改性不足，这主要是由于共混材料与基体之间的相容性差、亲水性材料在使用和储存过程中从基体中洗脱以及共混材料的表面富集不足。为了解决上述缺点，我们开发了新型聚醚砜/聚（丙烯酸-co-N-乙烯基-2-吡咯烷酮）网络状亚微凝胶（PES/P（AA-VP） NSs），将其与 PES 共混以提高 PES 膜的抗污染性、抗菌黏附性和血液相容性。结果表明，PES/P（AA-VP） NSs 与 PES 基体具有良好的相容性，亲水性亚微凝胶会在相转化过程中由于表面分离而富集在膜表面。PES 基体与网络状亚微凝胶之间的缠结会有效地限制亚微凝胶的洗脱。总之，通过与 PES/P（AA-VP） NSs 共混制备的改性 PES 膜可能会因其在血液透析领域的应用而受到广泛关注。
