Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, PR China; Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Department of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong, China.
Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:576-582. doi: 10.1016/j.msec.2018.11.074. Epub 2018 Nov 29.
A gradient porous microneedle array (GPMA) is developed for transdermal drug delivery. A modified hot embossing approach is proposed to fabricate the GPMA from poly (lactic-co-glycolic acid) powders within a cavity array mold under the coupling combination of gradient thermal and pressure multi-fields. The porosity of the microneedles is a gradient, and the pores are mainly distributed in the tip region. The liquid drug formulation can directly be loaded in the pores of the microneedle tips by dipping. GPMA could penetrate into the rabbit skin without breakage and the penetration force per microneedle is approximately 22 mN. The GPMA can diffuse a dry model drug, namely Rhodamine B, in vitro in the rabbit skin dermis. The GPMA can also effectively deliver an insulin solution in vivo in diabetes rats, lowering the blood glucose levels. Above all, as a dry or liquid drug carrier and a minimally invasive injector, the GPMA offers an effective alternative for transdermal drug delivery.
梯度多孔微针阵列（GPMA）用于透皮给药。提出了一种改进的热压印方法，通过在腔体阵列模具内的聚（乳酸-共-乙醇酸）粉末中，在梯度热和压力多场的耦合组合下，制造 GPMA。微针的孔隙率为梯度，并且孔隙主要分布在针尖区域。液体药物制剂可以通过浸渍直接加载到微针针尖的孔中。GPMA 可以无破损地穿透兔子皮肤，每根微针的穿透力约为 22 mN。GPMA 可以在体外将干燥模型药物，即 Rhodamine B，扩散到兔皮真皮中。GPMA 还可以在糖尿病大鼠体内有效输送胰岛素溶液，降低血糖水平。总之，作为一种干燥或液体药物载体和微创注射器，GPMA 为透皮药物输送提供了一种有效的替代方案。
