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生物医学中微阵列贴片的发展进展。

Advances in the development of microarray patches in biomedicine.

作者信息

Makvandi Pooyan, Jamaledin Rezvan, Mofidfar Mohammad, Wang Xiangdong, Moon Tae Seok

机构信息

The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, China.

University of Bath, Department of Life Sciences, Claverton Down, Bath BA2 7AY, United Kingdom.

出版信息

N Biotechnol. 2025 May 25;86:25-30. doi: 10.1016/j.nbt.2025.01.003. Epub 2025 Jan 14.

DOI:10.1016/j.nbt.2025.01.003
PMID:39814261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11928244/
Abstract

Microarray patches (MAPs) have been employed to deliver therapeutic payloads and for detection purposes. Research has been conducted to develop novel designs in material chemistry and the architecture of microarray, which have opened up the possibility for broader applications of MAPs. However, MAPs have yet to be clinically implemented fully. Addressing the current challenges and maximizing opportunities will pave the way to translate the relevant technologies from bench to bedside.

摘要

微阵列贴片(MAPs)已被用于递送治疗性药物和用于检测目的。人们开展了相关研究来开发材料化学和微阵列架构方面的新颖设计,这为MAPs的更广泛应用开辟了可能性。然而,MAPs尚未完全在临床上得到应用。应对当前挑战并最大化机遇将为将相关技术从实验室转化到临床应用铺平道路。

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Nat Commun. 2023 Jun 10;14(1):3431. doi: 10.1038/s41467-023-39129-6.
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3D-Printed Microarray Patches for Transdermal Applications.用于透皮应用的3D打印微阵列贴片
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Single-digit-micrometer-resolution continuous liquid interface production.单微米级分辨率连续液界面制造
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Stimuli-responsive transdermal microneedle patches.刺激响应型透皮微针贴片
Mater Today (Kidlington). 2021 Jul-Aug;47:206-222. doi: 10.1016/j.mattod.2021.03.012. Epub 2021 May 20.
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Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study.mRNA-1273疫苗皮内分次剂量给药的安全性和免疫原性:一项概念验证研究。
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