Shandong University Taishan College (Biological Research Training Program for Top-notch Students).
Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University.
Biosci Trends. 2019 Jan 22;12(6):526-536. doi: 10.5582/bst.2018.01172. Epub 2018 Dec 28.
Dietary polyphenols, a natural component in many kinds of foods such as fruits and vegetables, play essential roles in a wide range of plant functions. Importantly, the discovery of the functions of polyphenols including anti-oxidant, anti-carcinogenic and anti-inflammatory has been appealing to researchers' attentions. Dietary polyphenols have shown protective effects on chronic degenerative diseases (CDD) such as cardiovascular diseases, cancers, and neurodegenerative diseases by regulating gene expression. Dietary polyphenols also affect the composition and activity of gut microbiota, in reverse, gut microbiota influences the bioavailability and physiological activity of dietary polyphenols. However, not all kinds of dietary polyphenols are beneficial for human health. The potential deleterious effects of several dietary polyphenols have been reported by inducing DNA damage and gene mutants. This review summarizes the potential therapeutic effects of dietary polyphenols on chronic degeneration diseases, the polyphenols-gut microbiota interactions, and the potential dangers of individual dietary polyphenols on human health.
膳食多酚是多种食物（如水果和蔬菜）中的一种天然成分，在植物的许多功能中起着至关重要的作用。重要的是，多酚的功能（包括抗氧化、抗癌和抗炎）的发现引起了研究人员的关注。膳食多酚通过调节基因表达，对心血管疾病、癌症和神经退行性疾病等慢性退行性疾病（CDD）显示出保护作用。膳食多酚还影响肠道微生物群的组成和活性，相反，肠道微生物群影响膳食多酚的生物利用度和生理活性。然而，并非所有种类的膳食多酚都有益于人类健康。一些膳食多酚通过诱导 DNA 损伤和基因突变已经被报道具有潜在的有害作用。本综述总结了膳食多酚对慢性退行性疾病的潜在治疗作用、多酚-肠道微生物群的相互作用以及个别膳食多酚对人类健康的潜在危险。
