Shklair I L, Ralls S A
Naval Dental Research Institute, Naval Training Center, Great Lakes, Illinois 60088-5259.
Microbios. 1988;55(222):25-31.
The rice rat spontaneously develops periodontal disease, and this process can be accelerated if the animal is placed on a high sucrose diet. As the aetiological agent(s) is unknown, this study was undertaken to determine the micro-organisms associated with bone loss. Animals at weaning were placed on either a high sucrose diet or on regular rat chow and were sampled periodically for a variety of micro-organisms. Bacteroides spp., spirochetes, and Actinobacillus actinomycetemcomitans were not isolated from any animals, but fusiform-like organisms and Capnocytophaga spp. were isolated occasionally. An unidentified organism which had characteristics of both A. actinomycetemcomitans and Haemophilus aphrophilus was isolated from all animals at every sampling. Whether this organism is the primary aetiological agent of periodontal disease in the rice rat remains to be determined. Over the 12 week experimental period the animals on the high sucrose diet had significantly more exposed root surface than animals on regular rat chow.
稻鼠会自发患上牙周病，如果给这种动物喂食高蔗糖饮食，这一过程会加速。由于致病因素不明，开展本研究以确定与骨质流失相关的微生物。断奶后的动物被喂食高蔗糖饮食或常规大鼠食物，并定期采集样本检测多种微生物。未从任何动物中分离出拟杆菌属、螺旋体和伴放线放线杆菌，但偶尔分离出梭形样微生物和二氧化碳嗜纤维菌属。在每次采样时，从所有动物中都分离出一种兼具伴放线放线杆菌和嗜沫嗜血杆菌特征的未鉴定微生物。这种微生物是否是稻鼠牙周病的主要致病因素仍有待确定。在12周的实验期内，喂食高蔗糖饮食的动物比喂食常规大鼠食物的动物有更多的牙根表面暴露。
